Beta-adrenergic receptor kinase
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='Human BARK1 complex with RNA and Mg+2 ion (green) (PDB code [[3uzt]])' scene='70/705677/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Human BARK1 complex with RNA and Mg+2 ion (green) (PDB code [[3uzt]])' scene='70/705677/Cv/1'> | ||
| - | '''Beta adrenergic receptor kinase''' (BARK), currently termed GRK2 for G protein-coupled receptor kinase 2, is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β | + | '''Beta adrenergic receptor kinase''' or '''G-protein coupled receptor kinase''' (BARK), currently termed GRK2 for G protein-coupled receptor kinase 2, is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adrenergic receptor (BAR) as well as many other G protein-coupled receptors when they are occupied by the agonist thus causing their desensitization. BARK belongs to the family of G protein-coupled receptor kinases (GRK) that encompases 5 different isozymes. <ref>PMID:2871555</ref> |
<scene name='70/705677/Cv/4'>Human BARK1 complex with RNA and Mg+2 ion</scene>; | <scene name='70/705677/Cv/4'>Human BARK1 complex with RNA and Mg+2 ion</scene>; | ||
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of β adrenergic receptor kinase == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | [[1ym7]] – bBARK1 (mutant) - bovine <BR /> | ||
| - | [[5uvc]], [[5uuu]] – hBARK1 + inhibitor - human <BR /> | ||
| - | [[4pnk]], [[3cik]], [[5he3]] – hBARK1 + guanine-nucleotide binding protein G β,γ subunits <BR /> | ||
| - | [[3psc]], [[5he0]], [[5he1]], [[5he2]], [[6c2y]] – hBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits <BR /> | ||
| - | [[4mk0]], [[3v5w]] – hBARK1 + guanine-nucleotide binding protein G β,γ subunits + paroxetine derivative<BR /> | ||
| - | [[3uzs]] – hBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits + RNA <BR /> | ||
| - | [[3uzt]] – hBARK1 (mutant) + RNA <BR /> | ||
| - | [[3krw]], [[3krx]], [[5wg3]], [[5wg4]], [[5wg5]], [[5ukk]], [[5ukl]], [[5he3]] – hBARK1 + guanine-nucleotide binding protein G β,γ subunits + inhibitor<BR /> | ||
| - | [[3pvu]], [[3pvw]], [[5ukm]], [[5he0]], [[5he1]], [[5he2]] – bBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits + inhibitor <BR /> | ||
| - | [[2bcj]] – bBARK1 (mutant) + guanine-nucleotide binding protein G α,β,γ subunits <BR /> | ||
| - | [[1omw]] – bBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits <BR /> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801. PMID:2871555
- ↑ Tesmer VM, Lennarz S, Mayer G, Tesmer JJ. Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer. Structure. 2012 Jun 21. PMID:22727813 doi:10.1016/j.str.2012.05.002
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