Beta-adrenergic receptor kinase

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Current revision

↑ Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801. PMID:2871555
↑ Tesmer VM, Lennarz S, Mayer G, Tesmer JJ. Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer. Structure. 2012 Jun 21. PMID:22727813 doi:10.1016/j.str.2012.05.002

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 <StructureSection load='' size='350' side='right' caption='Human BARK1 complex with RNA and Mg+2 ion (green) (PDB code [[3uzt]])' scene='70/705677/Cv/1'>
-'''Beta adrenergic receptor kinase''' (BARK), currently termed GRK2 for G protein-coupled receptor kinase 2, is an intracellular serine/threonine kinase.  BARK is activated by protein kinase A.  BARK phosphorylates the β adregenic receptor (BAR) as well as many other G protein-coupled receptors when they is occupied by the agonist thus causing their desensitization.  BARK belongs to the family of G protein-coupled receptor kinases (GRK) that encompases 5 different isozymes. <ref>PMID:2871555</ref>
+'''Beta adrenergic receptor kinase''' or '''G-protein coupled receptor kinase''' (BARK), currently termed GRK2 for G protein-coupled receptor kinase 2, is an intracellular serine/threonine kinase.  BARK is activated by protein kinase A.  BARK phosphorylates the β adrenergic receptor (BAR) as well as many other G protein-coupled receptors when they are occupied by the agonist thus causing their desensitization.  BARK belongs to the family of G protein-coupled receptor kinases (GRK) that encompases 5 different isozymes. <ref>PMID:2871555</ref>
 <scene name='70/705677/Cv/4'>Human BARK1 complex with RNA and Mg+2 ion</scene>;