1iv5
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1iv5.gif|left|200px]] | [[Image:1iv5.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1iv5", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | | | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | + | --> | |
| - | + | {{STRUCTURE_1iv5| PDB=1iv5 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''New Crystal Form of Human CD81 Large Extracellular Loop.''' | '''New Crystal Form of Human CD81 Large Extracellular Loop.''' | ||
| Line 32: | Line 29: | ||
[[Category: Marco, P.]] | [[Category: Marco, P.]] | ||
[[Category: Petracca, R.]] | [[Category: Petracca, R.]] | ||
| - | [[Category: | + | [[Category: Alpha domain]] |
| - | [[Category: | + | [[Category: Five helix]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:27:28 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:27, 2 May 2008
New Crystal Form of Human CD81 Large Extracellular Loop.
Overview
The large extracellular loop of human CD81, a tetraspanin mediating hepatitis C virus envelope protein E2 binding to human cells, has been crystallized in a hexagonal form. The three-dimensional structure, solved and refined at 2.6 A resolution (R-factor = 22.8%), shows that the protein adopts a dimeric assembly, based on an association interface built up by tetraspanin-conserved residues. Structural comparisons with the tertiary structure of human CD81 large extracellular loop, previously determined in a different crystal form, show marked conformational fluctuations in the molecular regions thought to be involved in binding to the viral protein, suggesting rules for recognition and assembly within the tetraspan web.
About this Structure
1IV5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop., Kitadokoro K, Ponassi M, Galli G, Petracca R, Falugi F, Grandi G, Bolognesi M, Biol Chem. 2002 Sep;383(9):1447-52. PMID:12437138 Page seeded by OCA on Fri May 2 20:27:28 2008
