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8dwc

From Proteopedia

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'''Unreleased structure'''
 
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The entry 8dwc is ON HOLD
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==CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22==
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<StructureSection load='8dwc' size='340' side='right'caption='[[8dwc]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8dwc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DWC FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dwc OCA], [https://pdbe.org/8dwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dwc RCSB], [https://www.ebi.ac.uk/pdbsum/8dwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dwc ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PENK_BOVIN PENK_BOVIN] Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.[UniProtKB:P01210] Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.[UniProtKB:P01210] Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release.[UniProtKB:P22005] Increases glutamate release in the striatum and decreases GABA concentration in the striatum.[UniProtKB:P04094] Increases glutamate release in the striatum.[UniProtKB:P04094] Enkelytin possesses antibacterial activity against Gram-positive bacteria such as Micrococcus luteus and Bacillus megaterium.<ref>PMID:8654396</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Cao C]]
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[[Category: Fay JF]]
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[[Category: Liu Y]]
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[[Category: Roth BL]]

Current revision

CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22

PDB ID 8dwc

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