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4hd0

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==Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair==
==Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair==
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<StructureSection load='4hd0' size='340' side='right' caption='[[4hd0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4hd0' size='340' side='right'caption='[[4hd0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hd0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrfu Pyrfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HD0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hd0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HD0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mre11, PF1166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hd0 OCA], [https://pdbe.org/4hd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hd0 RCSB], [https://www.ebi.ac.uk/pdbsum/4hd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hd0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hd0 OCA], [http://pdbe.org/4hd0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hd0 RCSB], [http://www.ebi.ac.uk/pdbsum/4hd0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hd0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MRE11_PYRFU MRE11_PYRFU]] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity.
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[https://www.uniprot.org/uniprot/MRE11_PYRFU MRE11_PYRFU] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pyrfu]]
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[[Category: Large Structures]]
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[[Category: Kertokalio, A]]
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[[Category: Pyrococcus furiosus DSM 3638]]
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[[Category: Limbo, O]]
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[[Category: Kertokalio A]]
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[[Category: Moiani, D]]
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[[Category: Limbo O]]
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[[Category: Russell, P]]
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[[Category: Moiani D]]
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[[Category: Tainer, J A]]
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[[Category: Russell P]]
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[[Category: Wyman, C]]
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[[Category: Tainer JA]]
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[[Category: Dna binding protein]]
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[[Category: Wyman C]]
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[[Category: Double-strand break repair]]
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[[Category: Mutation l204r]]
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[[Category: Nbs1]]
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[[Category: Nuclease enzyme]]
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[[Category: Rad50]]
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Revision as of 08:11, 3 November 2022

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair

PDB ID 4hd0

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