Beta secretase 3D structures

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**[[2zhs]], [[2zht]], [[2zhu]], [[2zhv]], [[1sgz]] - hBACE-1 catalytic domain – human<br />
**[[2zhs]], [[2zht]], [[2zhu]], [[2zhv]], [[1sgz]] - hBACE-1 catalytic domain – human<br />
**[[1w50]], [[3tpj]], [[3tpl]], [[3zkg]] - hBACE-1 catalytic domain (mutant)<br />
**[[1w50]], [[3tpj]], [[3tpl]], [[3zkg]] - hBACE-1 catalytic domain (mutant)<br />
-
**[[3k5d]], [[3k5f]], [[3k5g]], [[3ixj]], [[3kmx]], [[3kmy]], [[3kn0]], [[3ivh]], [[3ivi]], [[2vkm]], [[2hiz]], [[2hm1]], [[2g94]], [[1xs7]], [[4fm7]], [[4fm8]], [[4gid]], [[4i0h]], [[5dqc]], [[5qco]], [[5qcp]], [[5qcq]], [[5qcr]], [[5qcs]], [[5qct]], [[5qcu]], [[5qcv]], [[5qcw]], [[5qcx]], [[5qcy]], [[5qcz]], [[5dq1]], [[5dq2]], [[5dq3]], [[5dq4]], [[5dq5]], [[5dq6]], [[5dq7]], [[5dq8]], [[5dq9]], [[5dqa]], [[5dqb]], [[5dqc]], [[5dqd]], [[6ej2]], [[6ej3]] – hBACE-1 catalytic domain+inhibitor<br />
+
**[[3k5d]], [[3k5f]], [[3k5g]], [[3ixj]], [[3kmx]], [[3kmy]], [[3kn0]], [[3ivh]], [[3ivi]], [[2vkm]], [[2hiz]], [[2hm1]], [[2g94]], [[1xs7]], [[4fm7]], [[4fm8]], [[4gid]], [[4i0h]], [[5dqc]], [[5qco]], [[5qcp]], [[5qcq]], [[5qcr]], [[5qcs]], [[5qct]], [[5qcu]], [[5qcv]], [[5qcw]], [[5qcx]], [[5qcy]], [[5qcz]], [[5dq1]], [[5dq2]], [[5dq3]], [[5dq4]], [[5dq5]], [[5dq6]], [[5dq7]], [[5dq8]], [[5dq9]], [[5dqa]], [[5dqb]], [[5dqc]], [[5dqd]], [[6ej2]], [[6ej3]], [[7d2v]], [[7d2x]], [[7d36]], [[7d5a]], [[7dcz]], [[7f1d]], [[7myi]], [[7myr]], [[7myu]], [[7n66]] – hBACE-1 catalytic domain+inhibitor<br />
**[[3lhg]], [[3ind]], [[3in3]], [[3in4]], [[3ine]], [[3inf]], [[3inh]], [[3ooz]], [[3s7l]], [[3s7m]], [[4dju]], [[4djv]], [[4djw]], [[4djx]], [[4djy]] – hBACE-1 catalytic domain+ aminohydantoin inhibitor<br />
**[[3lhg]], [[3ind]], [[3in3]], [[3in4]], [[3ine]], [[3inf]], [[3inh]], [[3ooz]], [[3s7l]], [[3s7m]], [[4dju]], [[4djv]], [[4djw]], [[4djx]], [[4djy]] – hBACE-1 catalytic domain+ aminohydantoin inhibitor<br />
**[[3fkt]] – hBACE-1 catalytic domain (mutant) + aminohydantoin inhibitor<br />
**[[3fkt]] – hBACE-1 catalytic domain (mutant) + aminohydantoin inhibitor<br />
**[[3k5c]], [[3l58]], [[3l59]], [[3l5b]], [[3l5c]], [[3l5d]], [[3l5e]], [[3l5f]], [[3duy]], [[3dv1]], [[3dv5]], [[2f3e]], [[2f3f]], [[1ym2]], [[1ym4]], [[3skf]], [[3skg]], [[4h1e]], [[4h3j]], [[4ha5]], [[4gmi]], [[4k8s]], [[4k9h]], [[6nv7]], [[6nv9]], [[6nw3]] – hBACE-1 catalytic domain+ macrocyclic inhibitor<br />
**[[3k5c]], [[3l58]], [[3l59]], [[3l5b]], [[3l5c]], [[3l5d]], [[3l5e]], [[3l5f]], [[3duy]], [[3dv1]], [[3dv5]], [[2f3e]], [[2f3f]], [[1ym2]], [[1ym4]], [[3skf]], [[3skg]], [[4h1e]], [[4h3j]], [[4ha5]], [[4gmi]], [[4k8s]], [[4k9h]], [[6nv7]], [[6nv9]], [[6nw3]] – hBACE-1 catalytic domain+ macrocyclic inhibitor<br />
-
**[[3ckp]], [[3ckr]], [[2qzk]], [[2ph8]], [[2va5]], [[2va6]], [[2va7]], [[2ph6]], [[4ke0]], [[4ke1]] – hBACE-1 catalytic domain (mutant) + macrocyclic inhibitor<br />
+
**[[3ckp]], [[3ckr]], [[2qzk]], [[2ph8]], [[2va5]], [[2va6]], [[2va7]], [[2ph6]], [[4ke0]], [[4ke1]], [[6uj1]] – hBACE-1 catalytic domain (mutant) + macrocyclic inhibitor<br />
**[[3ohh]], [[3ohf]], [[3n4l]], [[3nsh]], [[2iqg]], [[3pi5]], [[3qbh]], [[4dpf]], [[4dpi]], [[4dus]], [[4fs4]], [[4ewo]], [[4exg]], [[3veu]], [[3vf3]], [[3vg1]], [[4d83]], [[4d85]], [[4d88]]], [[4d89]], [[4d8c]], [[3qi1]], [[4lxa]], [[4lxk]], [[4lxm]] – hBACE-1 catalytic domain+ hydroxyethylamine inhibitor<br />
**[[3ohh]], [[3ohf]], [[3n4l]], [[3nsh]], [[2iqg]], [[3pi5]], [[3qbh]], [[4dpf]], [[4dpi]], [[4dus]], [[4fs4]], [[4ewo]], [[4exg]], [[3veu]], [[3vf3]], [[3vg1]], [[4d83]], [[4d85]], [[4d88]]], [[4d89]], [[4d8c]], [[3qi1]], [[4lxa]], [[4lxk]], [[4lxm]] – hBACE-1 catalytic domain+ hydroxyethylamine inhibitor<br />
**[[3i25]] – hBACE-1 catalytic domain+ hydroxyethylene inhibitor<br />
**[[3i25]] – hBACE-1 catalytic domain+ hydroxyethylene inhibitor<br />
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**[[2q11]], [[2q15]], [[4i0e]], [[4i0f]], [[4i0g]], [[4i10]], [[4i11]], [[4i12]], [[4i1c]], [[5mxd]], [[2wjo]] – hBACE-1 catalytic domain+ quinazoline inhibitor<br />
**[[2q11]], [[2q15]], [[4i0e]], [[4i0f]], [[4i0g]], [[4i10]], [[4i11]], [[4i12]], [[4i1c]], [[5mxd]], [[2wjo]] – hBACE-1 catalytic domain+ quinazoline inhibitor<br />
**[[2vnm]], [[2vnn]], [[2vie]], [[2vij]], [[2viy]], [[2viz]], [[2vj6]], [[2vj7]], [[2vj9]], [[4dh6]], [[4di2]] – hBACE-1 catalytic domain (mutant) + hydroxyethylamine inhibitor<br />
**[[2vnm]], [[2vnn]], [[2vie]], [[2vij]], [[2viy]], [[2viz]], [[2vj6]], [[2vj7]], [[2vj9]], [[4dh6]], [[4di2]] – hBACE-1 catalytic domain (mutant) + hydroxyethylamine inhibitor<br />
-
**[[4b78]], [[3l38]], [[3l3a]], [[6eqm]], [[6dmi]], [[6e3z]], [[6jsg]], [[6uvp]] – hBACE-1 catalytic domain + pyridine inhibitor<br />
+
**[[4b78]], [[3l38]], [[3l3a]], [[6eqm]], [[6dmi]], [[6e3z]], [[6jsg]], [[6uvp]], [[7b1e]], [[7b1p]], [[7b1q]], [[7d2v]], [[7d2x]], [[7d5a]], [[7dcz]] – hBACE-1 catalytic domain + pyridine inhibitor<br />
**[[2ohq]], [[2ohr]], [[2ohs]], [[2oht]], [[2ohu]], [[2ohp]], [[4j0p]], [[2ntr]], [[2ohm]], [[4azy]], [[4b00]], [[4b05]], [[3zmg]], [[4j0t]], [[4j0v]], [[4j0y]], [[4j0z]], [[4j1i]], [[4j1k]], [[3zov]], [[4bfd]] – hBACE-1 catalytic domain (mutant) + pyridine inhibitor<br />
**[[2ohq]], [[2ohr]], [[2ohs]], [[2oht]], [[2ohu]], [[2ohp]], [[4j0p]], [[2ntr]], [[2ohm]], [[4azy]], [[4b00]], [[4b05]], [[3zmg]], [[4j0t]], [[4j0v]], [[4j0y]], [[4j0z]], [[4j1i]], [[4j1k]], [[3zov]], [[4bfd]] – hBACE-1 catalytic domain (mutant) + pyridine inhibitor<br />
**[[2b8v]], [[2irz]], [[2xfi]], [[2xfj]], [[2xfk]], [[1w51]] – hBACE-1 catalytic domain (mutant) + benzamide inhibitor<br />
**[[2b8v]], [[2irz]], [[2xfi]], [[2xfj]], [[2xfk]], [[1w51]] – hBACE-1 catalytic domain (mutant) + benzamide inhibitor<br />
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**[[4acx]] – hBACE-1 catalytic domain (mutant) + aminoimidazole inhibitor<br />
**[[4acx]] – hBACE-1 catalytic domain (mutant) + aminoimidazole inhibitor<br />
**[[2zhr]], [[1xn2]], [[1xn3]], [[1m4h]], [[1fkn]], [[5mcq]] - hBACE-1 catalytic domain + peptide inhibitor<br />
**[[2zhr]], [[1xn2]], [[1xn3]], [[1m4h]], [[1fkn]], [[5mcq]] - hBACE-1 catalytic domain + peptide inhibitor<br />
-
**[[5mbw]], [[5mco]] - hBACE-1 catalytic domain (mutant) + peptide inhibitor<br />
+
**[[5mbw]], [[5mco]], [[6uj0]] - hBACE-1 catalytic domain (mutant) + peptide inhibitor<br />
**[[6wny]] – hBACE-1 catalytic domain + fluoro-olefin inhibitor<br />
**[[6wny]] – hBACE-1 catalytic domain + fluoro-olefin inhibitor<br />
**[[2oah]], [[1tqf]], [[3uqp]], [[3uqr]], [[3uqu]], [[3uqw]], [[3uqx]], [[4fgx]] - hBACE-1 catalytic domain (mutant)+inhibitor<br />
**[[2oah]], [[1tqf]], [[3uqp]], [[3uqr]], [[3uqu]], [[3uqw]], [[3uqx]], [[4fgx]] - hBACE-1 catalytic domain (mutant)+inhibitor<br />
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**[[3zkm]], [[3zkn]] - hBACE-2 extracellular domain + FAB<br />
**[[3zkm]], [[3zkn]] - hBACE-2 extracellular domain + FAB<br />
**[[3zkq]], [[3zks]], [[3zkx]], [[4bel]], [[4bfb]] - hBACE-2 extracellular domain + xaperon<br />
**[[3zkq]], [[3zks]], [[3zkx]], [[4bel]], [[4bfb]] - hBACE-2 extracellular domain + xaperon<br />
-
**[[6jsz]] - hBACE-2 extracellular domain + xaperon + pyrazine inhibitor<br />
+
**[[6jsz]], [[7d5b]], [[7d5u]], [[7f1g]], [[7n4n]] - hBACE-2 extracellular domain + xaperon + pyrazine inhibitor<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Beta secretase

Updated on 03-November-2022

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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