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7x5g

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'''Unreleased structure'''
 
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The entry 7x5g is ON HOLD until Paper Publication
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==Nrf2 (A510Y)-MafG heterodimer bound with CsMBE2==
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<StructureSection load='7x5g' size='340' side='right'caption='[[7x5g]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7x5g]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X5G FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x5g OCA], [https://pdbe.org/7x5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x5g RCSB], [https://www.ebi.ac.uk/pdbsum/7x5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x5g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAFG_HUMAN MAFG_HUMAN] Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity).[UniProtKB:Q76MX4]<ref>PMID:11154691</ref> <ref>PMID:8932385</ref> <ref>PMID:9421508</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Baba S]]
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[[Category: Hamada K]]
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[[Category: Motohashi H]]
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[[Category: Ogata K]]
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[[Category: Ohta T]]
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[[Category: Okada C]]
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[[Category: Sato K]]
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[[Category: Sengoku T]]
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[[Category: Shiina M]]
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[[Category: Suzuki K]]
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[[Category: Uchiyama A]]
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[[Category: Yamamoto M]]

Revision as of 07:26, 9 November 2022

Nrf2 (A510Y)-MafG heterodimer bound with CsMBE2

PDB ID 7x5g

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