8h11
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Closed Conformation== | |
| - | + | <StructureSection load='8h11' size='340' side='right'caption='[[8h11]], [[Resolution|resolution]] 2.72Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8h11]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus Severe acute respiratory syndrome coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H11 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h11 OCA], [https://pdbe.org/8h11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h11 RCSB], [https://www.ebi.ac.uk/pdbsum/8h11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h11 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: He | + | [https://www.uniprot.org/uniprot/SPIKE_SARS SPIKE_SARS] May down-regulate host tetherin (BST2) by lysosomal degradation, thereby counteracting its antiviral activity.<ref>PMID:31199522</ref> Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membrane fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:14670965</ref> <ref>PMID:15496474</ref> Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]<ref>PMID:19321428</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: Liu | + | <references/> |
| - | [[Category: Wang | + | __TOC__ |
| - | [[Category: Wang | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Severe acute respiratory syndrome coronavirus]] | ||
| + | [[Category: Fu L]] | ||
| + | [[Category: He J]] | ||
| + | [[Category: Li Z]] | ||
| + | [[Category: Liu Y]] | ||
| + | [[Category: Wang J]] | ||
| + | [[Category: Wang P]] | ||
| + | [[Category: Xiong X]] | ||
| + | [[Category: Zhang X]] | ||
Revision as of 07:39, 9 November 2022
Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Closed Conformation
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Categories: Large Structures | Severe acute respiratory syndrome coronavirus | Fu L | He J | Li Z | Liu Y | Wang J | Wang P | Xiong X | Zhang X
