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5ogw

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==Cryo-EM structure of jasplakinolide-stabilized malaria parasite F-actin at near-atomic resolution==
==Cryo-EM structure of jasplakinolide-stabilized malaria parasite F-actin at near-atomic resolution==
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<StructureSection load='5ogw' size='340' side='right'caption='[[5ogw]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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<SX load='5ogw' size='340' side='right' viewer='molstar' caption='[[5ogw]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ogw]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafx Plafx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OGW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ogw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_HB3 Plasmodium falciparum HB3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OGW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9UE:Jasplakinolide'>9UE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9UE:Jasplakinolide'>9UE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ogw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ogw OCA], [http://pdbe.org/5ogw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ogw RCSB], [http://www.ebi.ac.uk/pdbsum/5ogw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ogw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ogw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ogw OCA], [https://pdbe.org/5ogw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ogw RCSB], [https://www.ebi.ac.uk/pdbsum/5ogw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ogw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACT1_PLAFX ACT1_PLAFX]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actin assembles into short polymer microfilaments, these are thought to contribute to parasite gliding motility.
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[https://www.uniprot.org/uniprot/ACT1_PLAFX ACT1_PLAFX] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actin assembles into short polymer microfilaments, these are thought to contribute to parasite gliding motility.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Plafx]]
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[[Category: Plasmodium falciparum HB3]]
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[[Category: Ecken, J von der]]
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[[Category: Kumpula E-P]]
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[[Category: Kumpula, E P]]
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[[Category: Kursula I]]
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[[Category: Kursula, I]]
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[[Category: Pospich S]]
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[[Category: Pospich, S]]
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[[Category: Raunser S]]
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[[Category: Raunser, S]]
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[[Category: Vahokoski J]]
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[[Category: Vahokoski, J]]
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[[Category: Von der Ecken J]]
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[[Category: Cryo-em]]
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[[Category: Cytoskeleton]]
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[[Category: F-actin]]
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[[Category: Filament]]
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[[Category: Glideosome]]
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[[Category: Gliding motility]]
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[[Category: Ja]]
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[[Category: Jasplakinolide]]
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[[Category: Malaria parasite]]
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[[Category: Plasmodium]]
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[[Category: Structural protein]]
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[[Category: Thin filament]]
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Current revision

Cryo-EM structure of jasplakinolide-stabilized malaria parasite F-actin at near-atomic resolution

5ogw, resolution 3.80Å

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