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4i1n
From Proteopedia
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==R104A-ca1697 nanobody binding to the binary DHFR.folate complex== | ==R104A-ca1697 nanobody binding to the binary DHFR.folate complex== | ||
| - | <StructureSection load='4i1n' size='340' side='right' caption='[[4i1n]], [[Resolution|resolution]] 1.89Å' scene=''> | + | <StructureSection load='4i1n' size='340' side='right'caption='[[4i1n]], [[Resolution|resolution]] 1.89Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4i1n]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4i1n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1N FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1n OCA], [https://pdbe.org/4i1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1n RCSB], [https://www.ebi.ac.uk/pdbsum/4i1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1n ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
==See Also== | ==See Also== | ||
| - | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: | + | [[Category: Lama glama]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Barlow | + | [[Category: Barlow JN]] |
| - | [[Category: Oyen | + | [[Category: Oyen D]] |
| - | [[Category: Steyaert | + | [[Category: Steyaert J]] |
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Current revision
R104A-ca1697 nanobody binding to the binary DHFR.folate complex
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