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8d43

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'''Unreleased structure'''
 
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The entry 8d43 is ON HOLD
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==Cryo-EM structure of human Kidney Glucosidase II==
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<StructureSection load='8d43' size='340' side='right'caption='[[8d43]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
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Authors: Lyu, M., Yu, E.W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8d43]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D43 FirstGlance]. <br>
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Description: Cryo-EM structure of human Kidney Glucosidase II
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d43 OCA], [https://pdbe.org/8d43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d43 RCSB], [https://www.ebi.ac.uk/pdbsum/8d43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d43 ProSAT]</span></td></tr>
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[[Category: Yu, E.W]]
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</table>
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[[Category: Lyu, M]]
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== Disease ==
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[https://www.uniprot.org/uniprot/GANAB_HUMAN GANAB_HUMAN] Autosomal dominant polycystic kidney disease. The disease is caused by variants affecting the gene represented in this entry. GANAB variations may act as a disease modifier in autosomal dominant polycystic liver disease in patients who have causative mutations in other genes, such as PKHD1 or ALG8.<ref>PMID:28375157</ref> <ref>PMID:33097077</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GANAB_HUMAN GANAB_HUMAN] Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053).<ref>PMID:10929008</ref> <ref>PMID:27259053</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Lyu M]]
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[[Category: Yu EW]]

Current revision

Cryo-EM structure of human Kidney Glucosidase II

PDB ID 8d43

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