1j1c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1j1c.gif|left|200px]]
[[Image:1j1c.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1j1c |SIZE=350|CAPTION= <scene name='initialview01'>1j1c</scene>, resolution 2.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_1j1c", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1j1c| PDB=1j1c | SCENE= }}
-
|RELATEDENTRY=[[1j1b|1J1B]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j1c OCA], [http://www.ebi.ac.uk/pdbsum/1j1c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j1c RCSB]</span>
+
-
}}
+
'''Binary complex structure of human tau protein kinase I with ADP'''
'''Binary complex structure of human tau protein kinase I with ADP'''
Line 35: Line 32:
[[Category: Sugiura, I.]]
[[Category: Sugiura, I.]]
[[Category: Yokota, T.]]
[[Category: Yokota, T.]]
-
[[Category: adp]]
+
[[Category: Adp]]
-
[[Category: complex]]
+
[[Category: Complex]]
-
[[Category: kinase]]
+
[[Category: Kinase]]
-
[[Category: tau]]
+
[[Category: Tau]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:40:47 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:27:30 2008''
+

Revision as of 17:40, 2 May 2008

Image:1j1c.gif


PDB ID 1j1c

Drag the structure with the mouse to rotate
1j1c, resolution 2.10Å ()
Ligands: ,
Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Related: 1j1b
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Binary complex structure of human tau protein kinase I with ADP


Overview

Human tau-protein kinase I (TPK I; also known as glycogen synthase kinase 3 beta; GSK3 beta) is a serine/threonine protein kinase that participates in Alzheimer's disease. Here, binary complex structures of full-length TPK I/GSK3 beta with the ATP analogues ADP and AMPPNP solved by the X-ray diffraction method at 2.1 and 1.8 A resolution, respectively, are reported. TPK I/GSK3 beta is composed of three domains: an N-terminal domain consisting of a closed beta-barrel structure, a C-terminal domain containing a 'kinase fold' structure and a small extra-domain subsequent to the C-terminal domain. The catalytic site is between the two major domains and has an ATP-analogue molecule in its ATP-binding site. The adenine ring is buried in the hydrophobic pocket and interacts specifically with the main-chain atoms of the hinge loop. The overall structure and substrate-binding residues are similar to those observed in other Ser/Thr protein kinases, while Arg141 (which is not conserved among other Ser/Thr protein kinases) is one of the key residues for specific ATP/ADP recognition by TPK I/GSK3 beta. No residues are phosphorylated, while the orientation of the activation loop in TPK I/GSK3 beta is similar to that in phosphorylated CDK2 and ERK2, suggesting that TPK I/GSK3 beta falls into a conformation that enables it to be constitutively active.

About this Structure

1J1C is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta., Aoki M, Yokota T, Sugiura I, Sasaki C, Hasegawa T, Okumura C, Ishiguro K, Kohno T, Sugio S, Matsuzaki T, Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):439-46. Epub 2004, Feb 25. PMID:14993667 Page seeded by OCA on Fri May 2 20:40:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1j1c"
Personal tools