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4ioq

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==Crystal Structure of the first bromodomain of BRD4 in complex with pyrrolidin-2-one==
==Crystal Structure of the first bromodomain of BRD4 in complex with pyrrolidin-2-one==
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<StructureSection load='4ioq' size='340' side='right' caption='[[4ioq]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4ioq' size='340' side='right'caption='[[4ioq]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ioq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IOQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ioq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IOQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAQ:PYRROLIDIN-2-ONE'>BAQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAQ:PYRROLIDIN-2-ONE'>BAQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ioo|4ioo]], [[4ior|4ior]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ioq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ioq OCA], [https://pdbe.org/4ioq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ioq RCSB], [https://www.ebi.ac.uk/pdbsum/4ioq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ioq ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ioq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ioq OCA], [http://pdbe.org/4ioq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ioq RCSB], [http://www.ebi.ac.uk/pdbsum/4ioq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ioq ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Bromodomain-containing protein|Bromodomain-containing protein]]
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Battistutta, R]]
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[[Category: Large Structures]]
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[[Category: Lolli, G]]
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[[Category: Battistutta R]]
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[[Category: Bromodomain]]
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[[Category: Lolli G]]
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[[Category: Dna binding protein]]
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[[Category: Low mw fragment]]
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Revision as of 21:00, 16 November 2022

Crystal Structure of the first bromodomain of BRD4 in complex with pyrrolidin-2-one

PDB ID 4ioq

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