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4j3e

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==The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a==
==The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a==
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<StructureSection load='4j3e' size='340' side='right' caption='[[4j3e]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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<StructureSection load='4j3e' size='340' side='right'caption='[[4j3e]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4j3e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J3E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4j3e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J3E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ipf|4ipf]], [[1rv1|1rv1]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3e OCA], [https://pdbe.org/4j3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j3e RCSB], [https://www.ebi.ac.uk/pdbsum/4j3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j3e ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mdm2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3e OCA], [http://pdbe.org/4j3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j3e RCSB], [http://www.ebi.ac.uk/pdbsum/4j3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j3e ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
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[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[MDM2|MDM2]]
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*[[MDM2 3D structures|MDM2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: African clawed frog]]
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[[Category: Large Structures]]
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[[Category: Crowther, R]]
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[[Category: Xenopus laevis]]
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[[Category: Graves, B J]]
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[[Category: Crowther R]]
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[[Category: Kammlott, R U]]
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[[Category: Graves BJ]]
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[[Category: Lukacs, C M]]
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[[Category: Kammlott RU]]
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[[Category: E3 ubiquitin ligase]]
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[[Category: Lukacs CM]]
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[[Category: Imidazoline]]
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[[Category: Ligase-antagonist complex]]
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[[Category: Mdm2]]
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[[Category: Nucleus]]
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[[Category: P53]]
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[[Category: Protein-protein interaction]]
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Revision as of 21:30, 16 November 2022

The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a

PDB ID 4j3e

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