1j2e

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[[Image:1j2e.jpg|left|200px]]
[[Image:1j2e.jpg|left|200px]]
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{{Structure
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|PDB= 1j2e |SIZE=350|CAPTION= <scene name='initialview01'>1j2e</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1j2e", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span>
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{{STRUCTURE_1j2e| PDB=1j2e | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2e OCA], [http://www.ebi.ac.uk/pdbsum/1j2e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j2e RCSB]</span>
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'''Crystal structure of Human Dipeptidyl peptidase IV'''
'''Crystal structure of Human Dipeptidyl peptidase IV'''
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[[Category: Sugiyama, S.]]
[[Category: Sugiyama, S.]]
[[Category: Yamamoto, A.]]
[[Category: Yamamoto, A.]]
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[[Category: beta-propeller structure]]
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[[Category: Beta-propeller structure]]
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[[Category: cd26]]
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[[Category: Cd26]]
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[[Category: dipeptidyl peptidase iv]]
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[[Category: Dipeptidyl peptidase iv]]
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[[Category: prolyl oligopeptidase]]
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[[Category: Prolyl oligopeptidase]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:43:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:27:55 2008''
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Revision as of 17:43, 2 May 2008

Image:1j2e.jpg

Template:STRUCTURE 1j2e

Crystal structure of Human Dipeptidyl peptidase IV


Overview

Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the prolyl oligopeptidase (POP) family, and has been implicated in several diseases. Therefore, the development of DPPIV selective inhibitors, which are able to control the biological function of DPPIV, is important. We determined the crystal structure of human DPPIV at 2.6A resolution. The molecule consists of a unique eight-bladed beta-propeller domain in the N-terminal region and a serine protease domain in the C-terminal region. Also, the large "cave" structure, which is thought to control the access of the substrate, is found on the side of the beta-propeller fold. Comparison of the overall amino acid sequence between human DPPIV and POP shows low homology (12.9%). In this paper, we report the structure of human DPPIV, especially focusing on a unique eight-bladed beta-propeller domain. We also discuss the way for the access of the substrate to this domain.

About this Structure

1J2E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold., Hiramatsu H, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Yamamoto A, Shimizu R, Biochem Biophys Res Commun. 2003 Mar 21;302(4):849-54. PMID:12646248 Page seeded by OCA on Fri May 2 20:43:22 2008

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