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7zub
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7zub is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex== | |
| - | + | <StructureSection load='7zub' size='340' side='right'caption='[[7zub]], [[Resolution|resolution]] 2.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zub]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZUB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=JY6:(3~{Z})-3-(3-oxidanylidene-1~{H}-indol-2-ylidene)-1~{H}-indol-2-one'>JY6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MOO:MOLYBDATE+ION'>MOO</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zub OCA], [https://pdbe.org/7zub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zub RCSB], [https://www.ebi.ac.uk/pdbsum/7zub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zub ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ancelin A]] | ||
| + | [[Category: Bourguet W]] | ||
| + | [[Category: Bous J]] | ||
| + | [[Category: Grandvuillemin L]] | ||
| + | [[Category: Gruszczyk J]] | ||
| + | [[Category: Kwong HS]] | ||
| + | [[Category: Lai-Kee-Him J]] | ||
| + | [[Category: Savva CG]] | ||
Current revision
Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex
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