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4j7f

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'''Unreleased structure'''
 
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The entry 4j7f is ON HOLD until Paper Publication
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==SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy==
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<StructureSection load='4j7f' size='340' side='right'caption='[[4j7f]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4j7f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HOX:4-AMINO-L-PHENYLALANINE'>HOX</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7f OCA], [https://pdbe.org/4j7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7f RCSB], [https://www.ebi.ac.uk/pdbsum/4j7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref> <ref>PMID:15099517</ref> <ref>PMID:16141209</ref> <ref>PMID:17108971</ref> <ref>PMID:12540855</ref> <ref>PMID:15525938</ref>
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Authors: Horowitz, S., Del Rizzo, P.A., Trievel, R.C.
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Del Rizzo PA]]
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[[Category: Horowitz S]]
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[[Category: Trievel RC]]

Current revision

SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy

PDB ID 4j7f

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