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4j90

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Revision as of 10:59, 24 November 2022

Square-shaped octameric structure of KtrA with ATP bound

Structural highlights

4j90 is a 2 chain structure with sequence from Bacillus subtilis subsp. subtilis str. 168. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KTRA_BACSU Catalytic subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.^[1]

Publication Abstract from PubMed

In bacteria, archaea, fungi and plants the Trk, Ktr and HKT ion transporters are key components of osmotic regulation, pH homeostasis and resistance to drought and high salinity. These ion transporters are functionally diverse: they can function as Na(+) or K(+) channels and possibly as cation/K(+) symporters. They are closely related to potassium channels both at the level of the membrane protein and at the level of the cytosolic regulatory domains. Here we describe the crystal structure of a Ktr K(+) transporter, the KtrAB complex from Bacillus subtilis. The structure shows the dimeric membrane protein KtrB assembled with a cytosolic octameric KtrA ring bound to ATP, an activating ligand. A comparison between the structure of KtrAB-ATP and the structures of the isolated full-length KtrA protein with ATP or ADP reveals a ligand-dependent conformational change in the octameric ring, raising new ideas about the mechanism of activation in these transporters.

The structure of the KtrAB potassium transporter.,Vieira-Pires RS, Szollosi A, Morais-Cabral JH Nature. 2013 Apr 18;496(7445):323-8. doi: 10.1038/nature12055. PMID:23598340^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Holtmann G, Bakker EP, Uozumi N, Bremer E. KtrAB and KtrCD: two K+ uptake systems in Bacillus subtilis and their role in adaptation to hypertonicity. J Bacteriol. 2003 Feb;185(4):1289-98. PMID:12562800
↑ Vieira-Pires RS, Szollosi A, Morais-Cabral JH. The structure of the KtrAB potassium transporter. Nature. 2013 Apr 18;496(7445):323-8. doi: 10.1038/nature12055. PMID:23598340 doi:10.1038/nature12055

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4j90"

Categories: Bacillus subtilis subsp. subtilis str. 168 | Large Structures | Morais-Cabral JH | Vieira-Pires RS

@@ Line 1: / Line 1: @@
 ==Square-shaped octameric structure of KtrA with ATP bound==
-<StructureSection load='4j90' size='340' side='right' caption='[[4j90]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
+<StructureSection load='4j90' size='340' side='right'caption='[[4j90]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4j90]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J90 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4j90]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J90 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hms|2hms]], [[2hmt|2hmt]], [[2hmu|2hmu]], [[2hmv|2hmv]], [[2hmw|2hmw]], [[4j91|4j91]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j90 OCA], [https://pdbe.org/4j90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j90 RCSB], [https://www.ebi.ac.uk/pdbsum/4j90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j90 ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ktrA, yuaA, BSU31090 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j90 OCA], [http://pdbe.org/4j90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j90 RCSB], [http://www.ebi.ac.uk/pdbsum/4j90 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j90 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/KTRA_BACSU KTRA_BACSU]] Catalytic subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.<ref>PMID:12562800</ref>
+[https://www.uniprot.org/uniprot/KTRA_BACSU KTRA_BACSU] Catalytic subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.<ref>PMID:12562800</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 24: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Bacsu]]
+[[Category: Bacillus subtilis subsp. subtilis str. 168]]
-[[Category: Morais-Cabral, J H]]
+[[Category: Large Structures]]
-[[Category: Vieira-Pires, R S]]
+[[Category: Morais-Cabral JH]]
-[[Category: Cytosol]]
+[[Category: Vieira-Pires RS]]
-[[Category: Ktrb membrane protein]]
-[[Category: Metal transport]]
-[[Category: Potassium transport regulation]]
-[[Category: Rck domain]]
-[[Category: Square-shaped octameric ring]]

4j90

From Proteopedia

Revision as of 10:59, 24 November 2022

Square-shaped octameric structure of KtrA with ATP bound

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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