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4jap

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Current revision (11:02, 24 November 2022) (edit) (undo)
 
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==Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones==
==Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones==
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<StructureSection load='4jap' size='340' side='right' caption='[[4jap]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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<StructureSection load='4jap' size='340' side='right'caption='[[4jap]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jap]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JAP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jap]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JAP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14U:(2S)-2-METHYL-3-OXOOCTADECANOIC+ACID'>14U</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14U:(2S)-2-METHYL-3-OXOOCTADECANOIC+ACID'>14U</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jao|4jao]], [[4jaq|4jaq]], [[4jar|4jar]], [[4jat|4jat]], [[4jd3|4jd3]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jap OCA], [https://pdbe.org/4jap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jap RCSB], [https://www.ebi.ac.uk/pdbsum/4jap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jap ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pks11, Rv1665, MT1705 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jap OCA], [http://pdbe.org/4jap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jap RCSB], [http://www.ebi.ac.uk/pdbsum/4jap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jap ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PKS11_MYCTU PKS11_MYCTU]] Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products.
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[https://www.uniprot.org/uniprot/PKS11_MYCTU PKS11_MYCTU] Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gokulan, K]]
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[[Category: Large Structures]]
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[[Category: Sacchettini, J C]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project]]
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[[Category: Gokulan K]]
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[[Category: Alkylpyrone synthesis]]
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[[Category: Sacchettini JC]]
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[[Category: Enzyme function initiative]]
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[[Category: Ketosynthase enzyme]]
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[[Category: Lipid biosynthesis]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones

PDB ID 4jap

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