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4jo9

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Revision as of 11:26, 24 November 2022

Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex 1:2 stoichiometry

Structural highlights

4jo9 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NUP54_HUMAN Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

Publication Abstract from PubMed

The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. We present the reconstitution and interdisciplinary analyses of the ~425-kDa inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1*Nup49*Nup57 channel nucleoporin hetero-trimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT*Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. We propose that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation.

Architecture of the fungal nuclear pore inner ring complex.,Stuwe T, Bley CJ, Thierbach K, Petrovic S, Schilbach S, Mayo DJ, Perriches T, Rundlet EJ, Jeon YE, Collins LN, Huber FM, Lin DH, Paduch M, Koide A, Lu V, Fischer J, Hurt E, Koide S, Kossiakoff AA, Hoelz A Science. 2015 Aug 27. pii: aac9176. PMID:26316600^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Stuwe T, Bley CJ, Thierbach K, Petrovic S, Schilbach S, Mayo DJ, Perriches T, Rundlet EJ, Jeon YE, Collins LN, Huber FM, Lin DH, Paduch M, Koide A, Lu V, Fischer J, Hurt E, Koide S, Kossiakoff AA, Hoelz A. Architecture of the fungal nuclear pore inner ring complex. Science. 2015 Aug 27. pii: aac9176. PMID:26316600 doi:http://dx.doi.org/10.1126/science.aac9176

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4jo9"

@@ Line 3: / Line 3: @@
 <StructureSection load='4jo9' size='340' side='right'caption='[[4jo9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4jo9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JO9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4jo9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JO9 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jnu|4jnu]], [[4jnv|4jnv]], [[4jo7|4jo7]], [[4jq5|4jq5]]</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jo9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jo9 OCA], [https://pdbe.org/4jo9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jo9 RCSB], [https://www.ebi.ac.uk/pdbsum/4jo9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jo9 ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUP54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NUPL1, KIAA0410 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jo9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jo9 OCA], [http://pdbe.org/4jo9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jo9 RCSB], [http://www.ebi.ac.uk/pdbsum/4jo9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jo9 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NUP54_HUMAN NUP54_HUMAN]] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. [[http://www.uniprot.org/uniprot/NUPL1_HUMAN NUPL1_HUMAN]] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (By similarity).
+[https://www.uniprot.org/uniprot/NUP54_HUMAN NUP54_HUMAN] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 19: @@
 ==See Also==
-*[[Nucleoporin|Nucleoporin]]
+*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Bley, C J]]
+[[Category: Bley CJ]]
-[[Category: Hoelz, A]]
+[[Category: Hoelz A]]
-[[Category: Mayo, D J]]
+[[Category: Mayo DJ]]
-[[Category: Stuwe, T]]
+[[Category: Stuwe T]]
-[[Category: Nucleocytoplasmic transport]]
-[[Category: Transport protein]]

4jo9

From Proteopedia

Revision as of 11:26, 24 November 2022

Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex 1:2 stoichiometry

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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