Glyoxylate cycle
From Proteopedia
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The glyoxylate cycle, a variation of the [[tricarboxylic acid cycle]], is an anabolic pathway occurring in plants, bacteria, protists, and fungi. The glyoxylate cycle centers on the conversion of acetyl-CoA to succinate for the synthesis of carbohydrates. | The glyoxylate cycle, a variation of the [[tricarboxylic acid cycle]], is an anabolic pathway occurring in plants, bacteria, protists, and fungi. The glyoxylate cycle centers on the conversion of acetyl-CoA to succinate for the synthesis of carbohydrates. | ||
| - | The glyoxylate cycle uses | + | The glyoxylate cycle uses six of the eight enzymes associated with the tricarboxylic acid cycle: citrate synthase, aconitase, succinate dehydrogenase, fumarase, and malate dehydrogenase. |
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| + | 1) [[Citrate Synthase]] | ||
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| + | 4C <scene name='43/430893/Cv/3'>oxaloacetate</scene> to a 6C molecule <scene name='43/430893/Cv/4'>citrate</scene> | ||
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| + | 2) [[Aconitase]] | ||
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| + | 6C Citrate => 6C <scene name='43/430893/Cv/5'>cis-Aconitate</scene> | ||
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| + | 6C ''cis''-Aconitate => 6C <scene name='43/430893/Cv/6'>Isocitrate</scene> | ||
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| + | 3) [[Succinate Dehydrogenase]] | ||
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| + | <scene name='43/430893/Cv/10'>Succinate</scene> => <scene name='43/430893/Cv/11'>Fumarate</scene> | ||
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| + | The two cycles differ in that in the glyoxylate cycle, isocitrate is converted into <scene name='93/939250/Cv/1'>glyoxylate</scene> and succinate by isocitrate lyase (ICL) instead of into α-ketoglutarate. | ||
*[[Malate synthase]] | *[[Malate synthase]] | ||
Revision as of 12:57, 28 November 2022
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