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CREB-binding protein

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<StructureSection load='3p1c' size='350' side='right' scene='54/541099/Cv/1' caption='Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]]'>
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[[Image:1kbh.png|left|200px|thumb|Crystal structure of CREB-binding protein (green) complex with nuclear receptor coactivator (grey) [[1kbh]]]]
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{{STRUCTURE_3p1c| PDB=3p1c | SIZE=350| SCENE= |right|CAPTION=Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]] }}
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== Function ==
== Function ==
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'''CREB-binding protein''' (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref>
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'''CREB-binding protein''' or '''CREBBP''' (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref>
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 interacts with the N-terminal of p73.
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CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.
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== 3D Structures of CREB-binding protein ==
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<scene name='54/541099/Cv/5'>Acetyllysine binding site</scene> with chain A. Water molecules are shown as red spheres.
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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<scene name='54/541099/Cv/6'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*CBP
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== 3D Structures of CREB-binding protein ==
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[[CREB-binding protein 3D structures]]
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**[[4i9o]] – mCBP GACKIX domain (mutant) - mouse <br />
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**[[1f81]] – mCBP TAZ2 domain - NMR <br />
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**[[1u2n]] – mCBP TAZ1 domain - NMR <br />
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**[[1jjs]] – mCBP IBiD domain - NMR<br />
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**[[1liq]] – mCBP CH1 domain - NMR<br />
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**[[1tot]] – mCBP ZZ domain – NMR <br />
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**[[2kkj]] – mCBP nuclear coactivator binding domain - NMR <br />
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**[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
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**[[2d82]] – hCBP bromodomain - NMR<br />
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**[[3dwy]] – hCBP bromodomain <br />
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**[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]] – hCBP bromodomain + small molecule<br />
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**[[2l84]], [[2l85]] – hCBP bromodomain + small molecule - NMR<br />
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*CBP complex with protein
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</StructureSection>
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**[[1kbh]] – hCBP + nuclear receptor coactivator - NMR <br />
 
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**[[1zoq]] – hCBP + interferon regulatory factor 3 <br />
 
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**[[2c52]] – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR<br />
 
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**[[1r8u]] – mCBP TAZ1 domain + P300-interacting transactivator - NMR <br />
 
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**[[1l8c]] – mCBP TAZ1 domain + hypoxia-inducible factor 1α - NMR<br />
 
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**[[2lww]] - mCBP TAZ1 domain + nuclear transcription factor RELA – NMR <br />
 
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**[[2ka6]] – mCBP TAZ2 domain + STAT1-TAD - NMR<br />
 
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**[[2ka4]] – mCBP TAZ2 domain + STAT2-TAD - NMR<br />
 
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**[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />
 
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**[[2kje]] – hCBP TAZ2 domain + adenoviral E1A peptide - NMR<br />
 
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**[[1jsp]] – hCBP bromodomain + p53 peptide - NMR<br />
 
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**[[2l14]] – mCBP nuclear coactivator binding domain + p53 peptide - NMR<br />
 
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**[[1sb0]] – mCBP KIX domain + protein c-Myb – NMR <br />
 
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**[[2agh]] – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR <br />
 
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**[[2lqh]], [[2lqi]] – mCBP KIX domain + forkhead box O3 – NMR <br />
 
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**[[2kwf]] – hCBP KIX domain + transcription factor 4 – NMR <br />
 
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**[[2lxs]], [[2lxt]] – hCBP KIX domain + histone methyltransferase MLL peptide – NMR <br />
 
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**[[2rny]] – hCBP bromodomain + histone H3 peptide - NMR<br />
 
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**[[4n3w]], [[4n4f]] - hCBP bromodomain + histone H4 peptide <br />
 
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**[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain + ligand<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions 3p1c

Drag the structure with the mouse to rotate

References

  1. ↑ Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28;365(6449):855-9. PMID:8413673 doi:http://dx.doi.org/10.1038/365855a0
  2. ↑ Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ, et al.. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature. 1995 Jul 27;376(6538):348-51. PMID:7630403 doi:http://dx.doi.org/10.1038/376348a0
  3. ↑ Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell. 2012 Mar 30;149(1):214-31. PMID:22464331 doi:10.1016/j.cell.2012.02.013

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Michal Harel, Alexander Berchansky

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