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4jvf

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==The Crystal structure of PDE6D in complex with the inhibitor (s)-5==
==The Crystal structure of PDE6D in complex with the inhibitor (s)-5==
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<StructureSection load='4jvf' size='340' side='right' caption='[[4jvf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4jvf' size='340' side='right'caption='[[4jvf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jvf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JVF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jvf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JVF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=17X:(2S)-2-(2-PHENYL-1H-BENZIMIDAZOL-1-YL)-2-(PIPERIDIN-4-YL)ETHYL+1-(1-BENZYL-1H-BENZIMIDAZOL-2-YL)PIPERIDINE-4-CARBOXYLATE'>17X</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=17X:(2S)-2-(2-PHENYL-1H-BENZIMIDAZOL-1-YL)-2-(PIPERIDIN-4-YL)ETHYL+1-(1-BENZYL-1H-BENZIMIDAZOL-2-YL)PIPERIDINE-4-CARBOXYLATE'>17X</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jv6|4jv6]], [[4jv8|4jv8]], [[4jvb|4jvb]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvf OCA], [https://pdbe.org/4jvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jvf RCSB], [https://www.ebi.ac.uk/pdbsum/4jvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvf ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE6D, PDED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvf OCA], [http://pdbe.org/4jvf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jvf RCSB], [http://www.ebi.ac.uk/pdbsum/4jvf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
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[https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4jvf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4jvf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bastiaens, P]]
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[[Category: Large Structures]]
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[[Category: Chandra, A]]
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[[Category: Bastiaens P]]
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[[Category: Gunther, Z]]
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[[Category: Chandra A]]
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[[Category: Hahn, S]]
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[[Category: Gunther Z]]
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[[Category: Hoffmann, M]]
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[[Category: Hahn S]]
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[[Category: Ismail, S]]
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[[Category: Hoffmann M]]
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[[Category: Papke, B]]
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[[Category: Ismail S]]
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[[Category: Triola, G]]
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[[Category: Papke B]]
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[[Category: Vartak, N]]
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[[Category: Triola G]]
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[[Category: Waldmann, H]]
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[[Category: Vartak N]]
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[[Category: Wittinghofer, A]]
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[[Category: Waldmann H]]
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[[Category: Gdi-like solubilizing factor]]
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[[Category: Wittinghofer A]]
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[[Category: Immunoglobulin-like beta-sandwich]]
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[[Category: Prenyl binding]]
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[[Category: Protein binding-inhibitor complex]]
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Revision as of 11:27, 30 November 2022

The Crystal structure of PDE6D in complex with the inhibitor (s)-5

PDB ID 4jvf

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