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4k7q

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==Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution==
==Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution==
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<StructureSection load='4k7q' size='340' side='right' caption='[[4k7q]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<StructureSection load='4k7q' size='340' side='right'caption='[[4k7q]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4k7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K7Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4k7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K7Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZLD:N-{[(5S)-3-(3-FLUORO-4-MORPHOLIN-4-YLPHENYL)-2-OXO-1,3-OXAZOLIDIN-5-YL]METHYL}ACETAMIDE'>ZLD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZLD:N-{[(5S)-3-(3-FLUORO-4-MORPHOLIN-4-YLPHENYL)-2-OXO-1,3-OXAZOLIDIN-5-YL]METHYL}ACETAMIDE'>ZLD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">acrB, acrE, b0462, JW0451 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7q OCA], [https://pdbe.org/4k7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k7q RCSB], [https://www.ebi.ac.uk/pdbsum/4k7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k7q ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7q OCA], [http://pdbe.org/4k7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k7q RCSB], [http://www.ebi.ac.uk/pdbsum/4k7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k7q ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
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[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Gupta, G]]
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[[Category: Large Structures]]
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[[Category: Hung, L W]]
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[[Category: Gupta G]]
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[[Category: Kim, C Y]]
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[[Category: Hung LW]]
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[[Category: Kim, H B]]
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[[Category: Kim CY]]
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[[Category: Murakami, S]]
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[[Category: Kim HB]]
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[[Category: Terwilliger, T C]]
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[[Category: Murakami S]]
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[[Category: Inner membrane resistance-nodulation-cell division efflux pump]]
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[[Category: Terwilliger TC]]
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[[Category: Membrane protein-antibiotic complex]]
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Revision as of 11:44, 30 November 2022

Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution

PDB ID 4k7q

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