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4ka4
From Proteopedia
(Difference between revisions)
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==Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)== | ==Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)== | ||
| - | <StructureSection load='4ka4' size='340' side='right' caption='[[4ka4]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='4ka4' size='340' side='right'caption='[[4ka4]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ka4]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4ka4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KA4 FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ka4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ka4 OCA], [https://pdbe.org/4ka4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ka4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ka4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ka4 ProSAT]</span></td></tr> |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Athanasiadis A]] |
| - | [[Category: Sanctis | + | [[Category: De Sanctis D]] |
| - | [[Category: | + | [[Category: De Rosa M]] |
| - | + | ||
| - | + | ||
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Revision as of 11:48, 30 November 2022
Crystal structure of a proteolytically defined Zbeta domain of human DAI (ZBP1, DLM-1)
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