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4kg5

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==Crystal Structure of AmpC beta-lactamase N152G Mutant in Complex with Cefotaxime==
==Crystal Structure of AmpC beta-lactamase N152G Mutant in Complex with Cefotaxime==
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<StructureSection load='4kg5' size='340' side='right' caption='[[4kg5]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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<StructureSection load='4kg5' size='340' side='right'caption='[[4kg5]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kg5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KG5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kg5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KG5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCZ:(2R)-2-[(1R)-1-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-2-OXOETHYL]-5-METHYLIDENE-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>PCZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEF:CEFOTAXIME,+C3+CLEAVED,+OPEN,+BOUND+FORM'>CEF</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jxg|4jxg]], [[4ken|4ken]], [[4kg2|4kg2]], [[4kg6|4kg6]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg5 OCA], [https://pdbe.org/4kg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kg5 RCSB], [https://www.ebi.ac.uk/pdbsum/4kg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kg5 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kg5 RCSB], [http://www.ebi.ac.uk/pdbsum/4kg5 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Baggett, V L.]]
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[[Category: Large Structures]]
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[[Category: Docter, B E.]]
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[[Category: Baggett VL]]
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[[Category: Powers, R A.]]
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[[Category: Docter BE]]
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[[Category: Wallar, B J.]]
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[[Category: Powers RA]]
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[[Category: Acyl-enzyme complex]]
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[[Category: Wallar BJ]]
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[[Category: Beta-lactamase]]
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[[Category: Cephalosporinase]]
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[[Category: Hydrolase-antibiotic complex]]
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[[Category: Serine hydrolase]]
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Current revision

Crystal Structure of AmpC beta-lactamase N152G Mutant in Complex with Cefotaxime

PDB ID 4kg5

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