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4kha

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==Structural basis of histone H2A-H2B recognition by the essential chaperone FACT==
==Structural basis of histone H2A-H2B recognition by the essential chaperone FACT==
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<StructureSection load='4kha' size='340' side='right' caption='[[4kha]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='4kha' size='340' side='right'caption='[[4kha]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kha]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KHA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kha]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KHA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTHT_0052370, CTHT_0052370 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), hist1h2aj, LOC494591 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kha OCA], [https://pdbe.org/4kha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kha RCSB], [https://www.ebi.ac.uk/pdbsum/4kha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kha ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kha OCA], [http://pdbe.org/4kha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kha RCSB], [http://www.ebi.ac.uk/pdbsum/4kha PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kha ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.[https://www.uniprot.org/uniprot/G0SDN1_CHATD G0SDN1_CHATD]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: African clawed frog]]
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[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
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[[Category: Halbach, F]]
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[[Category: Large Structures]]
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[[Category: Hassler, M]]
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[[Category: Xenopus laevis]]
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[[Category: Hondele, M]]
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[[Category: Halbach F]]
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[[Category: Ladurner, A G]]
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[[Category: Hassler M]]
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[[Category: Chaperone-nuclear protein complex]]
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[[Category: Hondele M]]
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[[Category: Chromatin]]
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[[Category: Ladurner AG]]
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[[Category: Histone chaperone]]
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[[Category: Histone]]
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[[Category: Nucleus]]
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[[Category: Pleckstrin-homology like]]
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[[Category: Tandem phl]]
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[[Category: Transcription]]
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[[Category: U-turn motif]]
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Revision as of 11:58, 30 November 2022

Structural basis of histone H2A-H2B recognition by the essential chaperone FACT

PDB ID 4kha

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