Cryptochrome

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== Function ==
== Function ==
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Cryptochrome (Cry) is a flavoprotein associated with the biological clock function. In ''Drosophila melanogaster'' it is also involved in blue-light photoreception<ref>PMID:18399544</ref>.
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'''Cryptochrome''' (Cry) is a flavoprotein associated with the biological clock function. In ''Drosophila melanogaster'' it is also involved in blue-light photoreception<ref>PMID:18399544</ref>.
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For details on cryptochrome 4 see [[Cryptochrome 4]].
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See also [[JMS/cryptochrome]] and [[Period circadian protein]].
== Disease ==
== Disease ==
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The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer<ref>PMID:22778400</ref>.
The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer<ref>PMID:22778400</ref>.
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</StructureSection>
 
== 3D Structures of cryptochrome ==
== 3D Structures of cryptochrome ==
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[[Cryptochrome 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[4i6e]], [[4k0r]], [[5t5x]] – mCry-1 – mouse <br />
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[[4jzy]], [[4gu5]], [[4k03]] – Cry-1 + FAD – ''Drosophila melanogaster'' <br />
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[[1u3c]] – AtCry-1 PHR domain + FAD - ''Arabidopsis thaliana''<br />
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[[1u3d]] – AtCry-1 PHR domain + FAD + AMPPNP<br />
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[[4ct0]] – mCry-1 + PER2 <br />
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[[4i6g]] – mCry-2 + FAD <br />
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[[4u8h]] – mCry-2 + PER2 <br />
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[[4mlp]] – mCry-2 + carbazol derivative <br />
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[[3zxs]] – Cry-2 + FAD – ''Rhodobacter sphaeroides'' <br />
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[[2j4d]], [[2ijg]] – AtCry-3 + FAD <br />
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[[2vtb]] – AtCry-3 + FAD + DNA<br />
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[[3fy4]] – AtCry 6-4 + FAD <br />
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[[1np7]] – Cry - ''Synechocystis'' <br />
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== References ==
== References ==

Current revision

Mouse cryptochrome-1 complex with FAD (PDB code 4i6g)

Drag the structure with the mouse to rotate

References

  1. ↑ Yoshii T, Todo T, Wulbeck C, Stanewsky R, Helfrich-Forster C. Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons. J Comp Neurol. 2008 Jun 20;508(6):952-66. doi: 10.1002/cne.21702. PMID:18399544 doi:http://dx.doi.org/10.1002/cne.21702
  2. ↑ Narasimamurthy R, Hatori M, Nayak SK, Liu F, Panda S, Verma IM. Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12662-7. doi:, 10.1073/pnas.1209965109. Epub 2012 Jul 9. PMID:22778400 doi:http://dx.doi.org/10.1073/pnas.1209965109

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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