Cytochrome bc1 complex

From Proteopedia

Revision as of 11:23, 5 December 2022

spinqualitylabelsall models Cytochrome bc1 containing Cb (green), Cc1 (yellow), RISP (beige) and Fe2S2 complex with stigmatellin (PDB entry 1zrt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Cytochrome bc1 (Cbc1) functions as the central pump which transfers protons across the cell membrane. The protons are used to power the rotation of ATP synthase. Cbc1 binds ubiquinol which carries hydrogen atoms. Cbc1 separates the protons and the electrons. The protons are released in the inner side of the membrane for use by ATP synthase and the electrons are transferred to cytochrome c or to the outer side of the membrane. Plants use cytochrome b6f in the same manner binding plastoquinol as a hydrogen carrier. Stigmatellin inhibits the Cbc1 electron transfer by binding to its quinone oxidation site. Antimycin inhibits Cbc1 by binding to its quinone reduction site.[1] More details in Complex_III_of_Electron_Transport_Chain. Structural highlights Cbc1 is a composed of 11 proteins and cofactors which include heme-carrying proteins like and and iron-sulfur cluster proteins like . The iron containing moieties are , (where vinyl side chain of heme are replaced by thioether) and . [2]

3D structures of cytochrome bc1

Updated on 05-December-2022

1bgy, 1be3, 1l0n, 1ntm - bCb + bCc1 + RISP – bovine
1qcr - bCb + bCc1 + RISP – Cα model
1sqp, 2fyu, 1l0l, 1ntk, 1pp9, 1ppj, 1sqb, 2a06, 1sqv, 1sqx, 1sqq - bCb + bCc1 + RISP + inhibitor
4d6u - bCb + bCc1 + RISP + antimalarial pyridone
1ntz - bCb + bCc1 + RISP + ubiquinone
1nu1, 6xvf - bCb + bCc1 + RISP + quinolone derivative
6nhg - bCb in respiratory complex
6fo2 - bCb in respiratory complex – Cryo EM
6haw, 6zfs, 6zft, 6zfu - bCb in respiratory complex + antimalarial inhibitor
6fo0, 6fo6 - bCb in respiratory complex + antimalarial inhibitor – Cryo EM
7o37, 7o3c, 7o3e, 7o3h - Cb in CICIII2 complex – mouse - Cryo EM
3cxh, 3h1h, 1bcc, 3h1h - cCb + cCc1 + RISP - chicken
3cwb, 3h1i, 3h1j, 3h1k, 3h1l, 3l70, 3l71, 3l72, 3l73, 3l74, 3l75, 3tgu, 3bcc, 2bcc, 3h1i - cCb + cCc1 + RISP + inhibitor
7jrg, 7jrp - Cb in III2 complex – bean - Cryo EM
2ibz, 1kyo, 1kb9, 1p84 - yCb + yCc1 + RISP + inhibitor - yeast
3cx5 - yCb + yCc1 + RISP
1ezv - yCb + yCc1 + RISP + antibody
6giq, 6hu9, 6t0b, 6t15, 6ymx - yCb in respiratory complex – Cryo EM
2fyn - RsCb (mutant) + Cc1 + RISP – Rhodobacter sphaeroides<BR /> 2qjk - RsCb (mutant) + RsCc1 + RISP + inhibitor
2qjp - RsCb + RsCc1 + RISP + inhibitor
2qjy - RsCb (mutant) + RsCc1 + RISP (mutant) + inhibitor
1zrt - Cb + Cc1 + RISP – Rhodobacter capsulatus
2yiu - Cb + Cc1 + RISP – Paracoccus denitrificans
7rja, 7rjb, 7rjc, 7rjd, 7rje - Cb in III2 complex – Candida albicans - Cryo EM
7e1v - MtCb in respiratory complex – Mycobacterium tuberculosis - Cryo EM
7e1w, 7e1x - MtCb in respiratory complex + drug - Cryo EM
7rh5, 7rh6, 7rh7 - Cb in CIII2CIV2 complex – Mycobacterium smegmatis - Cryo EM
7q21, 7qhm, 7qho - Cb in CIII2CIV2 complex – Corynebacterium glutamicum - Cryo EM

References

1. ↑ Crofts AR. The cytochrome bc1 complex: function in the context of structure. Annu Rev Physiol. 2004;66:689-733. PMID:14977419 doi:http://dx.doi.org/10.1146/annurev.physiol.66.032102.150251
2. ↑ Berry EA, Huang LS, Saechao LK, Pon NG, Valkova-Valchanova M, Daldal F. X-Ray Structure of Rhodobacter Capsulatus Cytochrome bc (1): Comparison with its Mitochondrial and Chloroplast Counterparts. Photosynth Res. 2004;81(3):251-75. PMID:16034531 doi:http://dx.doi.org/10.1023/B:PRES.0000036888.18223.0e