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7u4l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human GPX4-U46C in complex with MAC-5576== | |
| - | + | <StructureSection load='7u4l' size='340' side='right'caption='[[7u4l]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7u4l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LW1:thiophene-2-carbaldehyde'>LW1</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u4l OCA], [https://pdbe.org/7u4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4l RCSB], [https://www.ebi.ac.uk/pdbsum/7u4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4l ProSAT]</span></td></tr> |
| - | [[Category: Forouhar | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Stockwell | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Forouhar F]] | ||
| + | [[Category: Lin AJ]] | ||
| + | [[Category: Liu H]] | ||
| + | [[Category: Polychronidou V]] | ||
| + | [[Category: Soni RK]] | ||
| + | [[Category: Stockwell BR]] | ||
| + | [[Category: Wang Q]] | ||
| + | [[Category: Xia X]] | ||
Current revision
Crystal structure of human GPX4-U46C in complex with MAC-5576
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Categories: Homo sapiens | Large Structures | Forouhar F | Lin AJ | Liu H | Polychronidou V | Soni RK | Stockwell BR | Wang Q | Xia X
