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7vfx

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'''Unreleased structure'''
 
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The entry 7vfx is ON HOLD
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==The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL==
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<StructureSection load='7vfx' size='340' side='right'caption='[[7vfx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors: Wang, X.K., Chen, G., Liao, Q.W., Du, Y., Hu, H.L., Ye, D.Q.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7vfx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VFX FirstGlance]. <br>
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Description: The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vfx OCA], [https://pdbe.org/7vfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vfx RCSB], [https://www.ebi.ac.uk/pdbsum/7vfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vfx ProSAT]</span></td></tr>
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[[Category: Ye, D.Q]]
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</table>
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[[Category: Hu, H.L]]
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== Disease ==
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[[Category: Du, Y]]
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[https://www.uniprot.org/uniprot/FPR1_HUMAN FPR1_HUMAN] Susceptibility to localized juvenile periodontitis.
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[[Category: Chen, G]]
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== Function ==
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[[Category: Liao, Q.W]]
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[https://www.uniprot.org/uniprot/FPR1_HUMAN FPR1_HUMAN] High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520, PubMed:15210802). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed:15210802).<ref>PMID:10514456</ref> <ref>PMID:15153520</ref> <ref>PMID:2161213</ref> <ref>PMID:2176894</ref> <ref>PMID:25109685</ref> <ref>PMID:10514456</ref> <ref>PMID:1712023</ref> <ref>PMID:2161213</ref> <ref>PMID:2176894</ref>
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[[Category: Wang, X.K]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Staphylococcus aureus]]
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[[Category: Chen G]]
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[[Category: Du Y]]
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[[Category: Hu HL]]
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[[Category: Liao QW]]
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[[Category: Wang XK]]
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[[Category: Ye DQ]]

Current revision

The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL

PDB ID 7vfx

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OCA

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