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4kk0

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==Crystal Structure of TSC1 core domain from S. pombe==
==Crystal Structure of TSC1 core domain from S. pombe==
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<StructureSection load='4kk0' size='340' side='right' caption='[[4kk0]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='4kk0' size='340' side='right'caption='[[4kk0]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kk0]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KK0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kk0]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KK0 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kk1|4kk1]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk0 OCA], [https://pdbe.org/4kk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kk0 RCSB], [https://www.ebi.ac.uk/pdbsum/4kk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kk0 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPAC22F3.13, tsc1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Schizosaccharomyces pombe 972h-])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kk0 RCSB], [http://www.ebi.ac.uk/pdbsum/4kk0 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TSC1_SCHPO TSC1_SCHPO]] Together with tsc2, required for uptake of various amino-acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.<ref>PMID:12136010</ref> <ref>PMID:14718525</ref> <ref>PMID:16624901</ref>
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[https://www.uniprot.org/uniprot/TSC1_SCHPO TSC1_SCHPO] Together with tsc2, required for uptake of various amino-acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.<ref>PMID:12136010</ref> <ref>PMID:14718525</ref> <ref>PMID:16624901</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4kk0" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Schizosaccharomyces pombe 972h-]]
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[[Category: Gao, F]]
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[[Category: Gao F]]
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[[Category: Gong, W M]]
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[[Category: Gong WM]]
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[[Category: Lou, J Z]]
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[[Category: Lou JZ]]
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[[Category: Sun, W]]
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[[Category: Sun W]]
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[[Category: Wang, Z Z]]
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[[Category: Wang ZZ]]
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[[Category: Xu, W Q]]
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[[Category: Xu WQ]]
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[[Category: Zhong, Q]]
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[[Category: Zhong Q]]
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[[Category: Zhu, Y]]
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[[Category: Zhu Y]]
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[[Category: Heat repeat]]
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[[Category: Immune system]]
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[[Category: Tumor suppressor]]
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Current revision

Crystal Structure of TSC1 core domain from S. pombe

PDB ID 4kk0

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