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4kr7

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==Crystal structure of a 4-thiouridine synthetase - RNA complex with bound ATP==
==Crystal structure of a 4-thiouridine synthetase - RNA complex with bound ATP==
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<StructureSection load='4kr7' size='340' side='right' caption='[[4kr7]], [[Resolution|resolution]] 3.42&Aring;' scene=''>
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<StructureSection load='4kr7' size='340' side='right'caption='[[4kr7]], [[Resolution|resolution]] 3.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kr7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KR7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kr7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KR7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kr6|4kr6]], [[4kr9|4kr9]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kr7 OCA], [https://pdbe.org/4kr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kr7 RCSB], [https://www.ebi.ac.uk/pdbsum/4kr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kr7 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AAD36761, thiI, TM_1694 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_sulfurtransferase tRNA sulfurtransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.4 2.8.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kr7 OCA], [http://pdbe.org/4kr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kr7 RCSB], [http://www.ebi.ac.uk/pdbsum/4kr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kr7 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THII_THEMA THII_THEMA]] Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).
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[https://www.uniprot.org/uniprot/THII_THEMA THII_THEMA] Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thema]]
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[[Category: Large Structures]]
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[[Category: TRNA sulfurtransferase]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Ficner, R]]
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[[Category: Ficner R]]
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[[Category: Lakomek, K]]
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[[Category: Lakomek K]]
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[[Category: Neumann, P]]
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[[Category: Neumann P]]
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[[Category: 4-thiouridine synthesis]]
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[[Category: Adenylation]]
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[[Category: Pp-loop motif]]
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[[Category: Sulfurtransferase]]
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[[Category: Thiouridine]]
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[[Category: Thump domain]]
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[[Category: Transferase-rna complex]]
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[[Category: Trna modification]]
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Revision as of 09:08, 7 December 2022

Crystal structure of a 4-thiouridine synthetase - RNA complex with bound ATP

PDB ID 4kr7

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