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4kxd

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==Crystal structure of human aminopeptidase A complexed with glutamate and calcium==
==Crystal structure of human aminopeptidase A complexed with glutamate and calcium==
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<StructureSection load='4kxd' size='340' side='right' caption='[[4kxd]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='4kxd' size='340' side='right'caption='[[4kxd]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kxd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KXD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kxd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KXD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kx7|4kx7]], [[4kx8|4kx8]], [[4kx9|4kx9]], [[4kxa|4kxa]], [[4kxb|4kxb]], [[4kxc|4kxc]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxd OCA], [https://pdbe.org/4kxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kxd RCSB], [https://www.ebi.ac.uk/pdbsum/4kxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxd ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ENPEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_aminopeptidase Glutamyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.7 3.4.11.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kxd RCSB], [http://www.ebi.ac.uk/pdbsum/4kxd PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN]] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.
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[https://www.uniprot.org/uniprot/AMPE_HUMAN AMPE_HUMAN] Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4kxd" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Aminopeptidase|Aminopeptidase]]
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glutamyl aminopeptidase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, F]]
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[[Category: Large Structures]]
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[[Category: Lin, Y Y]]
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[[Category: Li F]]
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[[Category: Liu, C]]
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[[Category: Lin YY]]
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[[Category: Yang, Y]]
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[[Category: Liu C]]
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[[Category: Hydrolase]]
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[[Category: Yang Y]]
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[[Category: Zinc-aminopeptidase]]
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Current revision

Crystal structure of human aminopeptidase A complexed with glutamate and calcium

PDB ID 4kxd

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