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8ej5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Tail tip structure of Staphylococcus phage Andhra== | |
| + | <StructureSection load='8ej5' size='340' side='right'caption='[[8ej5]], [[Resolution|resolution]] 4.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8ej5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rakietenvirinae Rakietenvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EJ5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ej5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ej5 OCA], [https://pdbe.org/8ej5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ej5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ej5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ej5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1S6L1H0_9CAUD A0A1S6L1H0_9CAUD] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Staphylococcus epidermidis is an opportunistic pathogen of the human skin, often associated with infections of implanted medical devices. Staphylococcal picoviruses are a group of strictly lytic, short-tailed bacteriophages with compact genomes that are attractive candidates for therapeutic use. Here, we report the structure of the complete virion of S. epidermidis-infecting phage Andhra, determined using high-resolution cryo-electron microscopy, allowing atomic modeling of 11 capsid and tail proteins. The capsid is a T = 4 icosahedron containing a unique stabilizing capsid lining protein. The tail includes 12 trimers of a unique receptor binding protein (RBP), a lytic protein that also serves to anchor the RBPs to the tail stem, and a hexameric tail knob that acts as a gatekeeper for DNA ejection. Using structure prediction with AlphaFold, we identified the two proteins that comprise the tail tip heterooctamer. Our findings elucidate critical features for virion assembly, host recognition, and penetration. | ||
| - | + | Structure and host specificity of Staphylococcus epidermidis bacteriophage Andhra.,Hawkins NC, Kizziah JL, Hatoum-Aslan A, Dokland T Sci Adv. 2022 Dec 2;8(48):eade0459. doi: 10.1126/sciadv.ade0459. Epub 2022 Nov , 30. PMID:36449623<ref>PMID:36449623</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8ej5" style="background-color:#fffaf0;"></div> |
| - | [[Category: Dokland | + | == References == |
| - | [[Category: Hawkins | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rakietenvirinae]] | ||
| + | [[Category: Dokland T]] | ||
| + | [[Category: Hawkins NC]] | ||
| + | [[Category: Kizziah JL]] | ||
Current revision
Tail tip structure of Staphylococcus phage Andhra
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