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4l93
From Proteopedia
(Difference between revisions)
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<StructureSection load='4l93' size='340' side='right'caption='[[4l93]], [[Resolution|resolution]] 1.84Å' scene=''> | <StructureSection load='4l93' size='340' side='right'caption='[[4l93]], [[Resolution|resolution]] 1.84Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4l93]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4l93]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L93 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=S36:3,4-DIHYDROISOQUINOLIN-2(1H)-YL[2,4-DIHYDROXY-5-(PROPAN-2-YL)PHENYL]METHANONE'>S36</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S36:3,4-DIHYDROISOQUINOLIN-2(1H)-YL[2,4-DIHYDROXY-5-(PROPAN-2-YL)PHENYL]METHANONE'>S36</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l93 OCA], [https://pdbe.org/4l93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l93 RCSB], [https://www.ebi.ac.uk/pdbsum/4l93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l93 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> |
==See Also== | ==See Also== | ||
| - | *[[Heat Shock | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: He | + | [[Category: He J]] |
| - | [[Category: Li | + | [[Category: Li J]] |
| - | [[Category: Ren | + | [[Category: Ren J]] |
| - | [[Category: Xiong | + | [[Category: Xiong B]] |
| - | [[Category: Yang | + | [[Category: Yang M]] |
| - | + | ||
| - | + | ||
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Revision as of 10:45, 14 December 2022
Crystal structure of Human Hsp90 with S36
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Categories: Homo sapiens | Large Structures | He J | Li J | Ren J | Xiong B | Yang M
