4lcc
From Proteopedia
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==Crystal structure of a human MAIT TCR in complex with a bacterial antigen bound to humanized bovine MR1== | ==Crystal structure of a human MAIT TCR in complex with a bacterial antigen bound to humanized bovine MR1== | ||
| - | <StructureSection load='4lcc' size='340' side='right' caption='[[4lcc]], [[Resolution|resolution]] 3.26Å' scene=''> | + | <StructureSection load='4lcc' size='340' side='right'caption='[[4lcc]], [[Resolution|resolution]] 3.26Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4lcc]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4lcc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LCC FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1XL:1-DEOXY-1-[6-(HYDROXYMETHYL)-2,4-DIOXO-3,4-DIHYDROPTERIDIN-8(2H)-YL]-D-ARABINITOL'>1XL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1XL:1-DEOXY-1-[6-(HYDROXYMETHYL)-2,4-DIOXO-3,4-DIHYDROPTERIDIN-8(2H)-YL]-D-ARABINITOL'>1XL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lcc OCA], [https://pdbe.org/4lcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lcc RCSB], [https://www.ebi.ac.uk/pdbsum/4lcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lcc ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HMR1_BOVIN HMR1_BOVIN] Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (By similarity). May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity).[UniProtKB:Q8HWB0][UniProtKB:Q95460][https://www.uniprot.org/uniprot/B2MG_BOVIN B2MG_BOVIN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4lcc" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4lcc" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | ||
| + | *[[T-cell receptor 3D structures|T-cell receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Bos taurus]] |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Adams EJ]] |
| - | [[Category: | + | [[Category: Lopez-Sagaseta J]] |
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Revision as of 10:51, 14 December 2022
Crystal structure of a human MAIT TCR in complex with a bacterial antigen bound to humanized bovine MR1
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