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4lgc

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{{STRUCTURE_4lgc| PDB=4lgc | SCENE= }}
 
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===Crystal structure of a bile acid-coenzyme A ligase (baiB) from Clostridium scindens (VPI 12708) at 2.19 A resolution===
 
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==Function==
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==Crystal structure of a bile acid-coenzyme A ligase (baiB) from Clostridium scindens (VPI 12708) at 2.19 A resolution==
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[[http://www.uniprot.org/uniprot/BAIB_EUBSP BAIB_EUBSP]] Active with a large number of C-24 bile acids possessing unhindered C-24 carboxyl groups. Requires ATP and produces AMP and pyrophosphate in addition to the bile-acid CoA thioester.
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<StructureSection load='4lgc' size='340' side='right'caption='[[4lgc]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4lgc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_scindens Clostridium scindens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LGC FirstGlance]. <br>
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[[4lgc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGC OCA].
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lgc OCA], [https://pdbe.org/4lgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lgc RCSB], [https://www.ebi.ac.uk/pdbsum/4lgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lgc ProSAT]</span></td></tr>
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[[Category: Atp-dependent amp-binding enzyme family]]
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</table>
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[[Category: Jcsg]]
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== Function ==
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[[Category: Joint center for structural genomic]]
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[https://www.uniprot.org/uniprot/BAIB_CLOSV BAIB_CLOSV] Functions in the bile acid 7alpha-dehydroxylation pathway, which forms secondary bile acids via the 7alpha-dehydroxylation of primary bile acids, and is carried out by intestinal anaerobic bacteria. Catalyzes the initial step in this pathway, i.e. the ATP-dependent thioesterification of primary bile acids with coenzyme A. Is active with C-24 bile acids with free carboxyl groups such as cholate, deoxycholate and chenodeoxycholate. Produces AMP and pyrophosphate in addition to the bile acid-CoA thioester.<ref>PMID:1551828</ref>
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[[Category: Ligase]]
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== References ==
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[[Category: Lipoprotein]]
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<references/>
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[[Category: Protein structure initiative]]
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__TOC__
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[[Category: Psi-biology]]
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</StructureSection>
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[[Category: Structural genomic]]
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[[Category: Large Structures]]

Current revision

Crystal structure of a bile acid-coenzyme A ligase (baiB) from Clostridium scindens (VPI 12708) at 2.19 A resolution

PDB ID 4lgc

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