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4lgc
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==Crystal structure of a bile acid-coenzyme A ligase (baiB) from Clostridium scindens (VPI 12708) at 2.19 A resolution== | ==Crystal structure of a bile acid-coenzyme A ligase (baiB) from Clostridium scindens (VPI 12708) at 2.19 A resolution== | ||
| - | <StructureSection load='4lgc' size='340' side='right' caption='[[4lgc]], [[Resolution|resolution]] 2.19Å' scene=''> | + | <StructureSection load='4lgc' size='340' side='right'caption='[[4lgc]], [[Resolution|resolution]] 2.19Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4lgc]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4lgc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_scindens Clostridium scindens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LGC FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lgc OCA], [https://pdbe.org/4lgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lgc RCSB], [https://www.ebi.ac.uk/pdbsum/4lgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lgc ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BAIB_CLOSV BAIB_CLOSV] Functions in the bile acid 7alpha-dehydroxylation pathway, which forms secondary bile acids via the 7alpha-dehydroxylation of primary bile acids, and is carried out by intestinal anaerobic bacteria. Catalyzes the initial step in this pathway, i.e. the ATP-dependent thioesterification of primary bile acids with coenzyme A. Is active with C-24 bile acids with free carboxyl groups such as cholate, deoxycholate and chenodeoxycholate. Produces AMP and pyrophosphate in addition to the bile acid-CoA thioester.<ref>PMID:1551828</ref> |
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
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Current revision
Crystal structure of a bile acid-coenzyme A ligase (baiB) from Clostridium scindens (VPI 12708) at 2.19 A resolution
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