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Cytochrome P450 3D structures
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(Difference between revisions)
(New page: == 3D Structures of Cytochrome P450 == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| * human P450 1 family **...) |
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**[[6dwn]] - hP4501A1 + erlotinib<br /> | **[[6dwn]] - hP4501A1 + erlotinib<br /> | ||
**[[6dwm]] - hP4501A1 + bergamottin<br /> | **[[6dwm]] - hP4501A1 + bergamottin<br /> | ||
| - | **[[3pm0]] - hP4501B1+naphthoflavone<br /> | + | **[[3pm0]], [[6oyu]] - hP4501B1+naphthoflavone<br /> |
| - | **[[6iq5]] - hP4501B1 + inhibitor<br /> | + | **[[6iq5]], [[6o5y]] - hP4501B1 + inhibitor<br /> |
| + | **[[6oyv]] - P4501B1 + estradiol - synthetic<br /> | ||
* human P450 2 family | * human P450 2 family | ||
| Line 18: | Line 19: | ||
**[[1pq2]] - hP4502C8<br /> | **[[1pq2]] - hP4502C8<br /> | ||
**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br /> | **[[1og2]], [[1og5]] – hP4502C9 (mutant)<br /> | ||
| + | **[[7rl2]] – hP4502C9 (mutant)) + drug <br /> | ||
**[[4gqs]] - hP4502C19 catalytic domain<br /> | **[[4gqs]] - hP4502C19 catalytic domain<br /> | ||
**[[2f9q]], [[3qm4]] – hP4502D6<br /> | **[[2f9q]], [[3qm4]] – hP4502D6<br /> | ||
| Line 74: | Line 76: | ||
**[[4i4g]], [[4i4h]], [[4k9t]], [[4k9u]], [[4k9v]], [[4k9w]], [[4k9x]], [[5vc0]], [[5vce]] - hP4503A4 (mutant) + anti-HIV drug<br /> | **[[4i4g]], [[4i4h]], [[4k9t]], [[4k9u]], [[4k9v]], [[4k9w]], [[4k9x]], [[5vc0]], [[5vce]] - hP4503A4 (mutant) + anti-HIV drug<br /> | ||
**[[5g5j]] - hP4503A4 + anti-diabetic drug<br /> | **[[5g5j]] - hP4503A4 + anti-diabetic drug<br /> | ||
| + | **[[6oo9]], [[6ooa]], [[6oob]] - hP4503A4 + anti-hypertension drug<br /> | ||
**[[3ua1]] - hP4503A4 + ergocryptine<br /> | **[[3ua1]] - hP4503A4 + ergocryptine<br /> | ||
**[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br /> | **[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br /> | ||
| - | **[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]], [[6ma8]], [[6ma7]], [[6ma6]], [[6dal]], [[6daj]], [[6dag]], [[6dac]], [[6dab]], [[6daa]], [[6da8]], [[6da5]], [[6da3]], [[6da2]] - hP4503A4 + inhibitor <br /> | + | **[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]], [[6ma8]], [[6ma7]], [[6ma6]], [[6dal]], [[6daj]], [[6dag]], [[6dac]], [[6dab]], [[6daa]], [[6da8]], [[6da5]], [[6da3]], [[6da2]], [[6une]], [[6ung]], [[6unh]], [[6uni]], [[6unj]], [[6unk]], [[6unl]], [[6unm]], [[7ks8]], [[7ksa]], [[7ksh]], [[7kvh]], [[7kvi]], [[7kvj]], [[7kvn]], [[7kvo]], [[7kvs]], [[7uay]], [[7uaz]], [[7uf9]], [[7ufb]], [[7ufc]], [[7ufd]], [[7ufe]], [[7uff]] - hP4503A4 + inhibitor <br /> |
**[[5te8]] - hP4503A4 + sedation drug <br /> | **[[5te8]] - hP4503A4 + sedation drug <br /> | ||
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br /> | **[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br /> | ||
| + | **[[7lxl]] - hP4503A4 + testosterone <br /> | ||
**[[6mjm]] - hP4503A5 <br /> | **[[6mjm]] - hP4503A5 <br /> | ||
| - | **[[5veu]] - hP4503A5 + inhibitor<br /> | + | **[[5veu]], [[7sv2]] - hP4503A5 + inhibitor<br /> |
| + | **[[7lad]] - hP4503A7 + drug<br /> | ||
| + | **[[7mk8]] - hP4503A7 + dithiothreitol<br /> | ||
* human P450 7 family | * human P450 7 family | ||
| Line 89: | Line 95: | ||
*human P450 11 family | *human P450 11 family | ||
| - | **[[6m7x]] - hP450 CYP11B1 + | + | **[[6m7x]], [[7e7f]] - hP450 CYP11B1 + drug<br /> |
**[[4dvq]] - hP450 CYP11B2 + corticosterone<br /> | **[[4dvq]] - hP450 CYP11B2 + corticosterone<br /> | ||
| - | **[[4fdh]] - hP450 CYP11B2 + | + | **[[4fdh]], [[7m8v]] - hP450 CYP11B2 + drug<br /> |
| - | **[[4zgx]] - hP450 CYP11B2 + inhibitor<br /> | + | **[[4zgx]], [[6xz8]], [[6xz9]] - hP450 CYP11B2 + inhibitor<br /> |
* human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase) | * human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase) | ||
| - | **[[5uys]], [[3ruk]] - hP450 C17 + abiraterone derivative<br /> | + | **[[5uys]], [[3ruk]], [[6chi]], [[6cir]], [[6ciz]], [[6wr0]], [[6ww0]] - hP450 C17 + abiraterone derivative<br /> |
| - | **[[4nkv]] - hP450 C17 (mutant) + abiraterone derivative<br /> | + | **[[4nkv]], [[6wr1]] - hP450 C17 (mutant) + abiraterone derivative<br /> |
**[[5irq]] - hP450 C17 + orteronel<br /> | **[[5irq]] - hP450 C17 + orteronel<br /> | ||
**[[5irv]] - hP450 C17 + inhibitor<br /> | **[[5irv]] - hP450 C17 + inhibitor<br /> | ||
| Line 119: | Line 125: | ||
**[[2zby]] - hP450105A1 (mutant) | **[[2zby]] - hP450105A1 (mutant) | ||
| - | * P450 from ''Mycobacterium tuberculosis'' or sterol 14-α demethylase | + | * P450 from ''Mycobacterium tuberculosis'' or sterol 14-α demethylase; CYP121 is mycocyclosin synthase |
**[[2vku]], [[1h5z]] – MtP450 CYP51 - ''Mycobacterium tuberculosis''<br /> | **[[2vku]], [[1h5z]] – MtP450 CYP51 - ''Mycobacterium tuberculosis''<br /> | ||
| Line 126: | Line 132: | ||
**[[1ea1]] - MtP450 CYP51 (mutant)+ fluconazole<br /> | **[[1ea1]] - MtP450 CYP51 (mutant)+ fluconazole<br /> | ||
**[[1e9x]] - MtP450 CYP51 (mutant)+ phenylimidazole<br /> | **[[1e9x]] - MtP450 CYP51 (mutant)+ phenylimidazole<br /> | ||
| - | **[[3cxv]], [[3cxx]], [[3cxy]], [[3cxz]], [[3cy0]], [[3cy1]] - MtP450 CYP121 (mutant)<br /> | ||
**[[3g5f]], [[3g5h]], [[2ij5]], [[1n40]] – MtP450 CYP121<br /> | **[[3g5f]], [[3g5h]], [[2ij5]], [[1n40]] – MtP450 CYP121<br /> | ||
| + | **[[3cxv]], [[3cxx]], [[3cxy]], [[3cxz]], [[3cy0]], [[3cy1]] - MtP450 CYP121 (mutant)<br /> | ||
**[[2ij7]] - MtP450 CYP121+fluconazole<br /> | **[[2ij7]] - MtP450 CYP121+fluconazole<br /> | ||
| - | **[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]] - MtP450 CYP121+pyrazole derivative<br /> | + | **[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]], [[6geo]], [[6geq]] - MtP450 CYP121+pyrazole derivative<br /> |
| - | **[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]] - MtP450 CYP121 + piperazine derivative<br /> | + | **[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]], [[5wp2]] - MtP450 CYP121 + piperazine derivative<br /> |
| - | **[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]], [[5ibg]], [[5ibh]], [[5ibi]], [[5ibj]], [[5ibd]], [[5ibe]], [[5ibf]], [[5edt]] - MtP450 CYP121 + inhibitor<br /> | + | **[[6upg]], [[6upi]] - MtP450 CYP121 + cyf-4-ome<br /> |
| + | **[[6rq0]], [[6rq1]], [[6rq3]], [[6rq5]], [[6rq6]], [[6rq8]], [[6rq9]], [[6rqb]], [[6rqd]], [[6rqe]] - MtP450 CYP121 + dicyclo-Tyr derivative<br /> | ||
| + | **[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]], [[5ibg]], [[5ibh]], [[5ibi]], [[5ibj]], [[5ibd]], [[5ibe]], [[5ibf]], [[5edt]], [[5o4k]], [[5o4l]], [[5op9]], [[5opa]], [[6geo]], [[6geq]], [[6te7]], [[6tet]], [[6tev]], [[7nqm]], [[7nqn]], [[7nqo]] - MtP450 CYP121 + inhibitor<br /> | ||
**[[3ivi]], [[3iw0]], [[3ivy]] – MtP450 CYP125 <br /> | **[[3ivi]], [[3iw0]], [[3ivy]] – MtP450 CYP125 <br /> | ||
**[[3iw1]] - MtP450 CYP125+androstenedione<br /> | **[[3iw1]] - MtP450 CYP125+androstenedione<br /> | ||
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* P450cam or camphor-5 momooxygenase | * P450cam or camphor-5 momooxygenase | ||
| - | **[[ | + | **[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]], [[6wpl]] - PpP450cam - ''Pseudomona putida''<br /> |
| - | + | **[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]], [[6we6]], [[6wfl]] – PpP450cam (mutant) <br /> | |
**[[2qbo]] - PpP450cam (mutant)+cyanide<br /> | **[[2qbo]] - PpP450cam (mutant)+cyanide<br /> | ||
**[[1qmq]] - PpP450cam (mutant)+Ru substrate<br /> | **[[1qmq]] - PpP450cam (mutant)+Ru substrate<br /> | ||
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**[[3oia]], [[3ol5]], [[3p6m]], [[3p6n]], [[3p6o]], [[3p6p]], [[3poq]], [[3por]], [[3pos]], [[3pot]], [[3pou]], [[3pov]], [[3pow]], [[3pox]], [[3w9c]], [[5gxg]] - PpP450cam (mutant)+substrate analog<br /> | **[[3oia]], [[3ol5]], [[3p6m]], [[3p6n]], [[3p6o]], [[3p6p]], [[3poq]], [[3por]], [[3pos]], [[3pot]], [[3pou]], [[3pov]], [[3pow]], [[3pox]], [[3w9c]], [[5gxg]] - PpP450cam (mutant)+substrate analog<br /> | ||
**[[4jws]], [[4jwu]] - PpP450cam (mutant)+ putidaredoxin<br /> | **[[4jws]], [[4jwu]] - PpP450cam (mutant)+ putidaredoxin<br /> | ||
| - | **[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + hydroxycamphor<br /> | + | **[[4jx1]], [[6nbi]] - PpP450cam (mutant)+ putidaredoxin + camphor + hydroxycamphor<br /> |
**[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + CN<br /> | **[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + CN<br /> | ||
**[[2m56]] - PpP450cam + putidaredoxin + camphor <br /> | **[[2m56]] - PpP450cam + putidaredoxin + camphor <br /> | ||
| Line 184: | Line 192: | ||
**[[4c9p]] - NaP450cam (mutant) + camphor <br /> | **[[4c9p]] - NaP450cam (mutant) + camphor <br /> | ||
**[[4c9k]] - NaP450cam + camphor + hydroxycamphor<br /> | **[[4c9k]] - NaP450cam + camphor + hydroxycamphor<br /> | ||
| - | **[[4c9n]] - NaP450cam (mutant) + camphor + hydroxycamphor<br /> | + | **[[4c9n]], [[6wgw]] - NaP450cam (mutant) + camphor + hydroxycamphor<br /> |
**[[4c9l]] - NaP450cam + camphor + CN<br /> | **[[4c9l]] - NaP450cam + camphor + CN<br /> | ||
**[[4c9o]] - NaP450cam (mutant) + camphor + CN<br /> | **[[4c9o]] - NaP450cam (mutant) + camphor + CN<br /> | ||
| Line 230: | Line 238: | ||
**[[3cbd]], [[2bmh]], [[2j4s]], [[4zfa]], [[1bu7]] – BmP450 heme domain – ''Bacillus megaterium''<br /> | **[[3cbd]], [[2bmh]], [[2j4s]], [[4zfa]], [[1bu7]] – BmP450 heme domain – ''Bacillus megaterium''<br /> | ||
| - | **[[5zlh]], [[5zis]] - BmP450 heme domain + Mn-protoporphyrin<br /> | ||
**[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]], [[4rsn]], [[4zf6]], [[5dyp]], [[5e7y]], [[5e9z]], [[5jqu]], [[5jqv]], [[5ucw]] - BmP450 heme domain (mutant)<br /> | **[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]], [[4rsn]], [[4zf6]], [[5dyp]], [[5e7y]], [[5e9z]], [[5jqu]], [[5jqv]], [[5ucw]] - BmP450 heme domain (mutant)<br /> | ||
| + | **[[5zlh]], [[5zis]] - BmP450 heme domain + Mn-protoporphyrin<br /> | ||
**[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br /> | **[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br /> | ||
**[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br /> | **[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br /> | ||
| Line 237: | Line 245: | ||
**[[1smj]], [[5jq2]] - BmP450 heme domain (mutant) + palmitate derivative<br /> | **[[1smj]], [[5jq2]] - BmP450 heme domain (mutant) + palmitate derivative<br /> | ||
**[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br /> | **[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br /> | ||
| + | **[[6iao]] - BmP450 heme domain (mutant) + DTT<br /> | ||
**[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br /> | **[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br /> | ||
| - | **[[4kew]], [[4key]], [[4o4p]], [[4zf8]], [[6h1l]], [[6h1o]], [[6h1s]], [[6h1t]] - BmP450 heme domain (mutant) + drug<br /> | + | **[[4kew]], [[4key]], [[4o4p]], [[4zf8]], [[6h1l]], [[6h1o]], [[6h1s]], [[6h1t]], [[6hn8]] - BmP450 heme domain (mutant) + drug<br /> |
**[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br /> | **[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br /> | ||
**[[2ij2]], [[2hpd]] - BmP450102 heme domain<br /> | **[[2ij2]], [[2hpd]] - BmP450102 heme domain<br /> | ||
| + | **[[6jlv]], [[6jmh]], [[6jmw]], [[6js8]], [[6jvc]], [[6k24]], [[6k9s]] - BmP450102 heme domain + abietoyl-Trp<br /> | ||
| + | **[[6jzs]] - BmP450102 heme domain + abietoyl-Trp + pyridine<br /> | ||
| + | **[[6k3q]], [[6k58]], [[6jo1]] - BmP450102 heme domain + Phe derivative<br /> | ||
**[[4dqk]] - BmP450 FAD domain + FAD<br /> | **[[4dqk]] - BmP450 FAD domain + FAD<br /> | ||
**[[4dql]] - BmP450 FAD domain + NADP + FAD<br /> | **[[4dql]] - BmP450 FAD domain + NADP + FAD<br /> | ||
**[[3wsp]] - BmP450 heme domain + decoy molecule<br /> | **[[3wsp]] - BmP450 heme domain + decoy molecule<br /> | ||
**[[2uwh]] - BmP450102+palmitic acid<br /> | **[[2uwh]] - BmP450102+palmitic acid<br /> | ||
| - | **[[3ben]] - BmP450 heme domain + inhibitor<br /> | + | **[[3ben]], [[7egn]] - BmP450 heme domain + inhibitor<br /> |
**[[2j1m]] - BmP450102 heme domain +DMSO<br /> | **[[2j1m]] - BmP450102 heme domain +DMSO<br /> | ||
**[[5jtd]] - BmP450102 heme domain (mutant) +DMSO<br /> | **[[5jtd]] - BmP450102 heme domain (mutant) +DMSO<br /> | ||
| Line 254: | Line 266: | ||
**[[5b2v]], [[5b2y]], [[5xa3]], [[5xhj]] - BmP450 heme domain + amino acid derivative<br /> | **[[5b2v]], [[5b2y]], [[5xa3]], [[5xhj]] - BmP450 heme domain + amino acid derivative<br /> | ||
**[[5og9]] - BmP450 heme domain + testosterone<br /> | **[[5og9]] - BmP450 heme domain + testosterone<br /> | ||
| + | **[[6ly4]] - BmP450 heme domain (mutant) + testosterone<br /> | ||
**[[5b2u]], [[5b2w]], [[5b2x]] - BmP450 heme domain (mutant) + tryptophan derivative<br /> | **[[5b2u]], [[5b2w]], [[5b2x]] - BmP450 heme domain (mutant) + tryptophan derivative<br /> | ||
| + | **[[7ckn]], [[7con]], [[7coo]], [[7cp8]], [[7cx8]], [[7d0t]], [[7d0u]], [[7d1f]], [[7e46]], [[7w97]], [[7w9d]], [[7w9j]] - PmP450 heme domain CYP102A1 + inhibitor<br /> | ||
**[[4yt3]] - BmP450 CYP106A2 <br /> | **[[4yt3]] - BmP450 CYP106A2 <br /> | ||
**[[5iki]] - BmP450 CYP106A2 + abietic acid <br /> | **[[5iki]] - BmP450 CYP106A2 + abietic acid <br /> | ||
| Line 260: | Line 274: | ||
**[[5l91]], [[5l92]] - BmP450 CYP109E1 + corticosterone<br /> | **[[5l91]], [[5l92]] - BmP450 CYP109E1 + corticosterone<br /> | ||
**[[5l94]] - BmP450 CYP109E1 + testosterone<br /> | **[[5l94]] - BmP450 CYP109E1 + testosterone<br /> | ||
| + | **[[7f3h]] - P450 heme domain – ''Deinococcus aerius''<br /> | ||
| + | **[[7f3w]] - P450 heme domain – ''Deinococcus apachensis''<br /> | ||
| + | |||
| + | *Eukaryote P450 Cyp51 or lanosterol 14-alpha demethylase | ||
| + | |||
| + | **[[3juv]] – hCyp51<br /> | ||
| + | **[[3jus]], [[3ld6]], [[4uhi]], [[4uhl]] – hCyp51 + drug<br /> | ||
| + | **[[6uez]] – hCyp51 + lanosterol<br /> | ||
| + | **[[6q2t]] – hCyp51 + inhibitor<br /> | ||
| + | **[[5esi]], [[5esn]] – yCyp51 (mutant) - yeast<br /> | ||
| + | **[[5eab]], [[5eac]], [[5ead]], [[5eae]], [[5eaf]], [[5eag]], [[5eah]], [[7ryx]], [[8dl4]] – yCyp51 + inhibitor<br /> | ||
| + | **[[4wmz]], [[5eqb]], [[5hs1]], [[5ul0]], [[6e8q]], [[7ryx]] – yCyp51 + drug<br /> | ||
| + | **[[4zdy]], [[4zdz]], [[4ze0]], [[4ze1]], [[4ze2]], [[4ze3]], [[5ese]], [[5esf]], [[5esg]], [[5esh]], [[5esj]], [[5esk]], [[5esl]], [[5esm]], [[7ry8]], [[7ry9]], [[7rya]], [[7ryb]] – yCyp51 (mutant) + drug<br /> | ||
| + | **[[4lxj]] – yCyp51 + lanosterol<br /> | ||
| + | **[[5v5z]] – CaP450 CYP51 – ''Candida albicans''<br /> | ||
| + | **[[5tz1]] – CaP450 CYP51 + drug <br /> | ||
| + | **[[5fsa]] – CaP450 CYP51 (mutant) + drug <br /> | ||
| + | |||
| + | *Bacterial P450 Cyp51 or lanosterol 14-alpha demethylase | ||
| + | |||
| + | **[[6mi0]], [[7jj1]]– McP450 CYP51 – ''Methylcoccus capsulatus''<br /> | ||
| + | **[[7tef]] – MmP450 CYP51B1 – ''Mycobacterium marinum''<br /> | ||
| + | **[[3g1q]] – TbP450 CYP51 – ''Trypanosoma brucei''<br /> | ||
| + | **[[5jlc]] – P450 CYP51 – ''Candida glabrata<''br /> | ||
| + | **[[4bmm]], [[4by0]], [[4c0c]], [[4c27]], [[4c28]], [[4coh]], [[4uqh]], [[4uvr]] – P450 CYP51 + inhibitor – ''Trypanosoma cruzi''<br /> | ||
| + | **[[6fmo]] – P450 CYP51 (mutant) + obtosifoliol <br /> | ||
| + | **[[6mcw]] – McP450 CYP51 + detergent <br /> | ||
| + | **[[7snm]] – McP450 CYP51 + drug <br /> | ||
| + | **[[7rkr]] – NfP450 CYP51 + inhibitor<br /> | ||
| + | **[[2wv2]], [[2wx2]], [[2x2n]], [[3tik]] – TbP450 CYP51 + drug<br /> | ||
| + | **[[3gw9]], [[4bjk]], [[4g3j]], [[4g7g]] – TbP450 CYP51 + inhibitor<br /> | ||
| + | **[[3p99]] – TbP450 CYP51 + lanosterol derivative<br /> | ||
| + | **[[6ay4]], [[6ayb]], [[6ayc]] – NfP450 CYP51 + drug – ''Naegleria fowleri''<br /> | ||
| + | **[[3l4d]] – P450 CYP51 + drug – ''Leishmania infantum''<br /> | ||
* Other CYPs | * Other CYPs | ||
| Line 269: | Line 317: | ||
**[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br /> | **[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br /> | ||
**[[2rfb]] – PtP450 – ''Picrophilus torridus''<br /> | **[[2rfb]] – PtP450 – ''Picrophilus torridus''<br /> | ||
| - | **[[6gii]] – P450 – ''Tepidiphilus thermophilus''<br /> | + | **[[6gii]], [[6laa]] – P450 – ''Tepidiphilus thermophilus''<br /> |
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br /> | **[[1wiy]] – TtP450 – ''Thermus thermophilus''<br /> | ||
**[[4e2p]], [[5xw2]] - P450 – ''Streptococcus himastatinicus''<br /> | **[[4e2p]], [[5xw2]] - P450 – ''Streptococcus himastatinicus''<br /> | ||
| Line 275: | Line 323: | ||
**[[5ysm]] – AmP450 – ''Amycolatopsis mediterranei''<br /> | **[[5ysm]] – AmP450 – ''Amycolatopsis mediterranei''<br /> | ||
**[[6f0c]], [[6f0b]] - P450 TXTC – ''Streptomyces acidiscabies''<br /> | **[[6f0c]], [[6f0b]] - P450 TXTC – ''Streptomyces acidiscabies''<br /> | ||
| - | **[[5gwe]] – CgP450 | + | **[[5gwe]], [[7ccf]] – CgP450 CreJ – ''Corynebacterium glutamicum''<br /> |
**[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br /> | **[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br /> | ||
**[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br /> | **[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br /> | ||
| Line 283: | Line 331: | ||
**[[3a4z]], [[5gnm]], [[5gnl]] - PaP450 VDH (mutant)<br /> | **[[3a4z]], [[5gnm]], [[5gnl]] - PaP450 VDH (mutant)<br /> | ||
**[[3qi8]] – P450 – synthetic<br /> | **[[3qi8]] – P450 – synthetic<br /> | ||
| + | **[[3g1q]] – TbP450 CYP51 – ''Trypanosoma brucei''<br /> | ||
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br /> | **[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br /> | ||
**[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br /> | **[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br /> | ||
| + | **[[6j94]] - AtP450 CYP97A3 <br /> | ||
| + | **[[6l8i]] - AtP450 CYP97A3 (mutant)<br /> | ||
**[[5kyo]] - P450 CYP101J2 – ''Sphingobium yanoikuyae''<br /> | **[[5kyo]] - P450 CYP101J2 – ''Sphingobium yanoikuyae''<br /> | ||
**[[3nv5]], [[3nv6]], [[4dxy]] - NaP450 CYP101D2<br /> | **[[3nv5]], [[3nv6]], [[4dxy]] - NaP450 CYP101D2<br /> | ||
| + | **[[6n6q]] - P450 CYP102L1 – Mycobacterium phage adler<br /> | ||
**[[4oqs]] - AoP450 CYP105AS1<br /> | **[[4oqs]] - AoP450 CYP105AS1<br /> | ||
**[[3abb]] – SaP450 CYP105D6 - ''Streptomyces avermitilis''<br /> | **[[3abb]] – SaP450 CYP105D6 - ''Streptomyces avermitilis''<br /> | ||
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br /> | **[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br /> | ||
| - | **[[2z3u]] - | + | **[[2z3u]] - SgP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br /> |
**[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br /> | **[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br /> | ||
| + | **[[6l39]] - SrP450 CYP107G1 – ''Streptomyces rapamycinicus''<br /> | ||
**[[4wpz]] - SaP450 CYP107W1 <br /> | **[[4wpz]] - SaP450 CYP107W1 <br /> | ||
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br /> | **[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br /> | ||
| Line 299: | Line 352: | ||
**[[4rm4]] - BsP450 CYP109B1<br /> | **[[4rm4]] - BsP450 CYP109B1<br /> | ||
**[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br /> | **[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br /> | ||
| + | **[[6ro8]] - P450 CYP116B5 – ''Acinetobacter radioresistens''<br /> | ||
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br /> | **[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br /> | ||
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br /> | **[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br /> | ||
| - | **[[6cvc]] – MmP450 CYP124A1 | + | **[[6cvc]] – MmP450 CYP124A1<br /> |
**[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br /> | **[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br /> | ||
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br /> | **[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br /> | ||
| + | **[[7tlo]] – MmP450 CYP142A3 <br /> | ||
**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br /> | **[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br /> | ||
**[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br /> | **[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br /> | ||
**[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br /> | **[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br /> | ||
**[[6hqd]] – PsP450 CYP153 <br /> | **[[6hqd]] – PsP450 CYP153 <br /> | ||
| + | **[[7ant]] – PoP450 CYP153 - ''Polaromonas''<br /> | ||
**[[1gwi]] - ScP450 CYP154C1<br /> | **[[1gwi]] - ScP450 CYP154C1<br /> | ||
| - | **[[6a7i]] - SvP450 CYP154C4 – | + | **[[6a7i]] - SvP450 CYP154C4 – Streptomyces violaceruber<br /> |
**[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br /> | **[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br /> | ||
**[[3r9b]] – MsP450 CYP164A2 <br /> | **[[3r9b]] – MsP450 CYP164A2 <br /> | ||
| Line 316: | Line 372: | ||
**[[1n97]] – TtP450 CYP175A1<br /> | **[[1n97]] – TtP450 CYP175A1<br /> | ||
**[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br /> | **[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br /> | ||
| - | **[[2z3t]] - StrP450 CYP245A1 | + | **[[2z3t]] - StrP450 CYP245A1 <br /> |
**[[5liv]] - ScP450 CYP260A1 <br /> | **[[5liv]] - ScP450 CYP260A1 <br /> | ||
**[[6f85]] - ScP450 CYP260A1 (mutant)<br /> | **[[6f85]] - ScP450 CYP260A1 (mutant)<br /> | ||
**[[5hiw]] - ScP450 CYP260B1 <br /> | **[[5hiw]] - ScP450 CYP260B1 <br /> | ||
**[[6gk5]] - ScP450 CYP267B1 <br /> | **[[6gk5]] - ScP450 CYP267B1 <br /> | ||
| - | **[[6g71]] - P450 CYP1232A24 - ''Arthrobacter''<br /> | + | **[[6g71]] - P450 CYP1232A24 - ''Arthrobacter<''br /> |
| + | **[[6m4q]] - SspP450 – ''Streptomyces spectabilis''<br /> | ||
| + | **[[6j82]] - SbP450 TleB – ''Streptomyces blastmyceticus''<br /> | ||
| + | **[[7ayx]] - P450 AryC – ''Streptomyces filamentosus''<br /> | ||
| + | **[[7oq6]] - P450 Sas16 –'' Streptomyces calvus''<br /> | ||
| + | **[[6kbh]] – ReP450 – ''Rhodococcus erythropolis''<br /> | ||
| + | **[[7v40]] – RcP450 – ''Rhodococcus coprophilus''<br /> | ||
| + | **[[6zhz]] - SanP450 – ''Streptomyces antibioticus''<br /> | ||
| + | **[[7qan]] - P450 – ''Micromonospora maris"<br /> | ||
*Other CYPs complexes | *Other CYPs complexes | ||
**[[2rfc]] – PtP450+phenylimidazole<br /> | **[[2rfc]] – PtP450+phenylimidazole<br /> | ||
| - | **[[3wec]] – | + | **[[3wec]] – ReP450 + dihydroxy-aurachin Re <br /> |
**[[5ysw]] – AmP450+ rifamycin <br /> | **[[5ysw]] – AmP450+ rifamycin <br /> | ||
**[[5omu]] – AmP450+ syringol <br /> | **[[5omu]] – AmP450+ syringol <br /> | ||
**[[5oms]] – AmP450+ guaethol <br /> | **[[5oms]] – AmP450+ guaethol <br /> | ||
| - | **[[5ncb]] – AmP450+ | + | **[[5ncb]] – AmP450+ guaiacol <br /> |
**[[5omr]] – AmP450+ vanilin <br /> | **[[5omr]] – AmP450+ vanilin <br /> | ||
| + | **[[6hqk]], [[6hql]]. [[6hqm]], [[6hqn]], [[6hqo]], [[6hqp]] – AoP450 (mutant) + guaiacol<br /> | ||
| + | **[[6hqs]] – AoP450 + syringol<br /> | ||
| + | **[[6hqq]], [[6hqr]], [[6hqt]] – AoP450 (mutant) + syringol<br /> | ||
**[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br /> | **[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br /> | ||
**[[2zqx]] - BsP450 BS b +heptanoic acid<br /> | **[[2zqx]] - BsP450 BS b +heptanoic acid<br /> | ||
| Line 338: | Line 405: | ||
**[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br /> | **[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br /> | ||
**[[5xjn]] – CgP450 CREJ + ethylphenyl derivative<br /> | **[[5xjn]] – CgP450 CREJ + ethylphenyl derivative<br /> | ||
| - | **[[5fsa]] – P450 CYP51 (mutant) + posaconazole – ''Candida albicans''<br /> | ||
**[[2rch]], [[3dsi]] – AtP450 CYP74A+13(S)-HOD <br /> | **[[2rch]], [[3dsi]] – AtP450 CYP74A+13(S)-HOD <br /> | ||
**[[3dsj]] - AtP450 CYP74A (mutant)+13(S)-HOD<br /> | **[[3dsj]] - AtP450 CYP74A (mutant)+13(S)-HOD<br /> | ||
**[[2rcl]] - AtP450 CYP74A+vernolic acid<br /> | **[[2rcl]] - AtP450 CYP74A+vernolic acid<br /> | ||
| - | **[[ | + | **[[7p6l]] - P450 CYP505A30 + dodecanoic acid – ''Mycelyophthora thermophila"<br /> |
| + | **[[6a15]] - AtP450 CYP90B1 (mutant) + cholesterol<br /> | ||
| + | **[[6a16]] - AtP450 CYP90B1 (mutant) + uniconazole<br /> | ||
| + | **[[6a17]] - AtP450 CYP90B1 (mutant) + brassinazole<br /> | ||
| + | **[[6a18]] - AtP450 CYP90B1 (mutant) + hexanediol<br /> | ||
| + | **[[6j94]] - AtP450 CYP97A3 + retinal<br /> | ||
| + | **[[6l8j]] - AtP450 CYP97A3 (mutant) + retinal<br /> | ||
**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br /> | **[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br /> | ||
**[[2zbx]] - SgP450 CYP105A1+imidazole<br /> | **[[2zbx]] - SgP450 CYP105A1+imidazole<br /> | ||
| - | **[[5x7e]] - | + | **[[5x7e]] - SgP450 CYP105A1 (mutant)+vitamin D2<br / |
**[[3aba]] – SaP450 CYP105P1+filipin I <br /> | **[[3aba]] – SaP450 CYP105P1+filipin I <br /> | ||
**[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br /> | **[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br /> | ||
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br /> | **[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br /> | ||
| + | **[[7q9e]] - PmP450 CYP106A1 – Priestia megaterium<br /> | ||
| + | **[[7cvr]], [[7cx6]], [[7czi]] - PmP450 CYP106A1 + inhibitor<br /> | ||
**[[1jin]], [[1jip]] - SeP450 CYP107A1+ ketoconazole <br /> | **[[1jin]], [[1jip]] - SeP450 CYP107A1+ ketoconazole <br /> | ||
**[[1jio]], [[1oxa]] - SeP450 CYP107A1+6DEB<br /> | **[[1jio]], [[1oxa]] - SeP450 CYP107A1+6DEB<br /> | ||
**[[1eup]] – SeP450 CYP107A1+androstendione<br /> | **[[1eup]] – SeP450 CYP107A1+androstendione<br /> | ||
**[[1egy]] - SeP450 CYP107A1+aminophenanthrene<br /> | **[[1egy]] - SeP450 CYP107A1+aminophenanthrene<br /> | ||
| + | **[[6kzs]] - SgP450 CYP107F1 + imidazole<br /> | ||
| + | **[[6l3a]] - SrP450 CYP107G1 + drug<br /> | ||
**[[4wq0]] - SaP450 CYP107W1 + oligomycin<br /> | **[[4wq0]] - SaP450 CYP107W1 + oligomycin<br /> | ||
**[[2vzm]] – SvP450 CYP107L1 (mutant)+narbomycin<br /> | **[[2vzm]] – SvP450 CYP107L1 (mutant)+narbomycin<br /> | ||
**[[2c7x]] - SvP450 CYP107L1+narbomycin<br /> | **[[2c7x]] - SvP450 CYP107L1+narbomycin<br /> | ||
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450 CYP107L1+YC-17<br /> | **[[2cd8]], [[2ca0]], [[2c6h]] – SvP450 CYP107L1+YC-17<br /> | ||
| - | **[[2jjp]] - SeP450 CYP113A1 (mutant)+ketoconazole<br /> | ||
| - | **[[2xfh]] - SeP450 CYP113A1 (mutant)+clotrimazole<br /> | ||
| - | **[[1f4t]] - SsP450 CYP119+ phenylimidazole<br /> | ||
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br /> | **[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br /> | ||
| + | **[[7smz]] – MmP450 CYP142A3 + cholestenone<br /> | ||
**[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br /> | **[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br /> | ||
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br /> | **[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br /> | ||
| + | **[[7ao7]] – PoP450 CYP153 + octanol <br /> | ||
| + | **[[6to2]] - NfP450 CYP154C4 + androstan derivative – ''Nocardia farcinica'' <br /> | ||
| + | **[[4j6b]], [[4jbc]], [[4jbd]], [[4jbt]] - NfP450 CYP154C5 + hormone<br /> | ||
**[[6a7j]] - SvP450 CYP154C4 + testosterone <br /> | **[[6a7j]] - SvP450 CYP154C4 + testosterone <br /> | ||
**[[3r9c]] – MsP450 CYP164A2 + econazole<br /> | **[[3r9c]] – MsP450 CYP164A2 + econazole<br /> | ||
| - | **[[4do1]], [[4egm]], [[6c3j]], [[6c3h]], [[6c2d]], [[5yqh]], [[5yqa]], [[5uvb]], [[5u6w]], [[5u6u]], [[5u6t]], [[5kt1]], [[5kdb]] – RpP450 CYP199A4 + benzoate derivative<br /> | + | **[[4do1]], [[4egm]], [[6c3j]], [[6c3h]], [[6c2d]], [[5yqh]], [[5yqa]], [[5uvb]], [[5u6w]], [[5u6u]], [[5u6t]], [[5kt1]], [[5kdb]], [[6oow]], [[6pq6]], [[6pqd]], [[6pqs]], [[6pqw]], [[6prr]], [[6prs]], [[6u30]], [[6u31]], [[6u3k]], [[7jw5]], [[7jxb]], [[7kcs]], [[7n14]], [[7r8s]], [[7r8t]], [[7reh]] – RpP450 CYP199A4 + benzoate derivative<br /> |
| - | **[[5kdz]], [[5kdy]] – RpP450 CYP199A4 (mutant) + benzoate derivative<br /> | + | **[[5kdz]], [[5kdy]], [[6oox]] , [[7n60]]– RpP450 CYP199A4 (mutant) + benzoate derivative<br /> |
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br /> | **[[4egn]] – RpP450 CYP199A4 + veratric acid<br /> | ||
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br /> | **[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br /> | ||
| + | **[[6unn]] – RpP450 CYP199A4 + cinnamic acid derivative<br /> | ||
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br /> | **[[4ego]] – RpP450 CYP199A4 + indole derivative<br /> | ||
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br /> | **[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br /> | ||
| Line 377: | Line 455: | ||
**[[4r20]] - zP450 17A2 + abiraterone – zebra fish<br /> | **[[4r20]] - zP450 17A2 + abiraterone – zebra fish<br /> | ||
**[[6b82]] - zP450 17A1 (mutant) + abiraterone <br /> | **[[6b82]] - zP450 17A1 (mutant) + abiraterone <br /> | ||
| + | **[[4r21]] - zP450 17A2 + progesterone<br /> | ||
| + | **[[6m4p]] - SspP450 + antibiotic <br /> | ||
| + | **[[6zi3]], [[7zi7]] - SanP450 + rhamnose <br /> | ||
| + | **[[7q6x]] - SanP450 + erythronolide<br /> | ||
| + | **[[7q6r]], [[7q89]] - SanP450 (mutant) + erythronolide<br /> | ||
| + | **[[6j84]] - SbP450 TleB + hydroxyl analog<br /> | ||
| + | **[[6j83]] - SbP450 TleB + NMVT<br /> | ||
| + | **[[7v41]], [[7v45]], [[7v46]] – RcP450 + toluene derivative<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
3D Structures of Cytochrome P450
Updated on 15-December-2022
