Cytochrome P450 3D structures

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Line 19: Line 19:
**[[1pq2]] - hP4502C8<br />
**[[1pq2]] - hP4502C8<br />
**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
 +
**[[7rl2]] – hP4502C9 (mutant)) + drug <br />
**[[4gqs]] - hP4502C19 catalytic domain<br />
**[[4gqs]] - hP4502C19 catalytic domain<br />
**[[2f9q]], [[3qm4]] – hP4502D6<br />
**[[2f9q]], [[3qm4]] – hP4502D6<br />
Line 78: Line 79:
**[[3ua1]] - hP4503A4 + ergocryptine<br />
**[[3ua1]] - hP4503A4 + ergocryptine<br />
**[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br />
**[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br />
-
**[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]], [[6ma8]], [[6ma7]], [[6ma6]], [[6dal]], [[6daj]], [[6dag]], [[6dac]], [[6dab]], [[6daa]], [[6da8]], [[6da5]], [[6da3]], [[6da2]], [[6une]], [[6ung]], [[6unh]], [[6uni]], [[6unj]], [[6unk]], [[6unl]], [[6unm]] - hP4503A4 + inhibitor <br />
+
**[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]], [[6ma8]], [[6ma7]], [[6ma6]], [[6dal]], [[6daj]], [[6dag]], [[6dac]], [[6dab]], [[6daa]], [[6da8]], [[6da5]], [[6da3]], [[6da2]], [[6une]], [[6ung]], [[6unh]], [[6uni]], [[6unj]], [[6unk]], [[6unl]], [[6unm]], [[7ks8]], [[7ksa]], [[7ksh]], [[7kvh]], [[7kvi]], [[7kvj]], [[7kvn]], [[7kvo]], [[7kvs]], [[7uay]], [[7uaz]], [[7uf9]], [[7ufb]], [[7ufc]], [[7ufd]], [[7ufe]], [[7uff]] - hP4503A4 + inhibitor <br />
**[[5te8]] - hP4503A4 + sedation drug <br />
**[[5te8]] - hP4503A4 + sedation drug <br />
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br />
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br />
 +
**[[7lxl]] - hP4503A4 + testosterone <br />
**[[6mjm]] - hP4503A5 <br />
**[[6mjm]] - hP4503A5 <br />
-
**[[5veu]] - hP4503A5 + inhibitor<br />
+
**[[5veu]], [[7sv2]] - hP4503A5 + inhibitor<br />
 +
**[[7lad]] - hP4503A7 + drug<br />
 +
**[[7mk8]] - hP4503A7 + dithiothreitol<br />
* human P450 7 family
* human P450 7 family
Line 91: Line 95:
*human P450 11 family
*human P450 11 family
-
**[[6m7x]] - hP450 CYP11B1 + fadrozole<br />
+
**[[6m7x]], [[7e7f]] - hP450 CYP11B1 + drug<br />
**[[4dvq]] - hP450 CYP11B2 + corticosterone<br />
**[[4dvq]] - hP450 CYP11B2 + corticosterone<br />
-
**[[4fdh]] - hP450 CYP11B2 + fadrozole<br />
+
**[[4fdh]], [[7m8v]] - hP450 CYP11B2 + drug<br />
**[[4zgx]], [[6xz8]], [[6xz9]] - hP450 CYP11B2 + inhibitor<br />
**[[4zgx]], [[6xz8]], [[6xz9]] - hP450 CYP11B2 + inhibitor<br />
* human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase)
* human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase)
-
**[[5uys]], [[3ruk]], [[6chi]], [[6cir]], [[6ciz]] - hP450 C17 + abiraterone derivative<br />
+
**[[5uys]], [[3ruk]], [[6chi]], [[6cir]], [[6ciz]], [[6wr0]], [[6ww0]] - hP450 C17 + abiraterone derivative<br />
-
**[[4nkv]] - hP450 C17 (mutant) + abiraterone derivative<br />
+
**[[4nkv]], [[6wr1]] - hP450 C17 (mutant) + abiraterone derivative<br />
**[[5irq]] - hP450 C17 + orteronel<br />
**[[5irq]] - hP450 C17 + orteronel<br />
**[[5irv]] - hP450 C17 + inhibitor<br />
**[[5irv]] - hP450 C17 + inhibitor<br />
Line 121: Line 125:
**[[2zby]] - hP450105A1 (mutant)
**[[2zby]] - hP450105A1 (mutant)
-
* P450 from ''Mycobacterium tuberculosis'' or sterol 14-α demethylase
+
* P450 from ''Mycobacterium tuberculosis'' or sterol 14-α demethylase; CYP121 is mycocyclosin synthase
**[[2vku]], [[1h5z]] – MtP450 CYP51 - ''Mycobacterium tuberculosis''<br />
**[[2vku]], [[1h5z]] – MtP450 CYP51 - ''Mycobacterium tuberculosis''<br />
Line 128: Line 132:
**[[1ea1]] - MtP450 CYP51 (mutant)+ fluconazole<br />
**[[1ea1]] - MtP450 CYP51 (mutant)+ fluconazole<br />
**[[1e9x]] - MtP450 CYP51 (mutant)+ phenylimidazole<br />
**[[1e9x]] - MtP450 CYP51 (mutant)+ phenylimidazole<br />
-
**[[3cxv]], [[3cxx]], [[3cxy]], [[3cxz]], [[3cy0]], [[3cy1]] - MtP450 CYP121 (mutant)<br />
 
**[[3g5f]], [[3g5h]], [[2ij5]], [[1n40]] – MtP450 CYP121<br />
**[[3g5f]], [[3g5h]], [[2ij5]], [[1n40]] – MtP450 CYP121<br />
 +
**[[3cxv]], [[3cxx]], [[3cxy]], [[3cxz]], [[3cy0]], [[3cy1]] - MtP450 CYP121 (mutant)<br />
**[[2ij7]] - MtP450 CYP121+fluconazole<br />
**[[2ij7]] - MtP450 CYP121+fluconazole<br />
**[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]], [[6geo]], [[6geq]] - MtP450 CYP121+pyrazole derivative<br />
**[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]], [[6geo]], [[6geq]] - MtP450 CYP121+pyrazole derivative<br />
-
**[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]] - MtP450 CYP121 + piperazine derivative<br />
+
**[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]], [[5wp2]] - MtP450 CYP121 + piperazine derivative<br />
**[[6upg]], [[6upi]] - MtP450 CYP121 + cyf-4-ome<br />
**[[6upg]], [[6upi]] - MtP450 CYP121 + cyf-4-ome<br />
**[[6rq0]], [[6rq1]], [[6rq3]], [[6rq5]], [[6rq6]], [[6rq8]], [[6rq9]], [[6rqb]], [[6rqd]], [[6rqe]] - MtP450 CYP121 + dicyclo-Tyr derivative<br />
**[[6rq0]], [[6rq1]], [[6rq3]], [[6rq5]], [[6rq6]], [[6rq8]], [[6rq9]], [[6rqb]], [[6rqd]], [[6rqe]] - MtP450 CYP121 + dicyclo-Tyr derivative<br />
-
**[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]], [[5ibg]], [[5ibh]], [[5ibi]], [[5ibj]], [[5ibd]], [[5ibe]], [[5ibf]], [[5edt]], [[6geo]], [[6geq]] - MtP450 CYP121 + inhibitor<br />
+
**[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]], [[5ibg]], [[5ibh]], [[5ibi]], [[5ibj]], [[5ibd]], [[5ibe]], [[5ibf]], [[5edt]], [[5o4k]], [[5o4l]], [[5op9]], [[5opa]], [[6geo]], [[6geq]], [[6te7]], [[6tet]], [[6tev]], [[7nqm]], [[7nqn]], [[7nqo]] - MtP450 CYP121 + inhibitor<br />
**[[3ivi]], [[3iw0]], [[3ivy]] – MtP450 CYP125 <br />
**[[3ivi]], [[3iw0]], [[3ivy]] – MtP450 CYP125 <br />
**[[3iw1]] - MtP450 CYP125+androstenedione<br />
**[[3iw1]] - MtP450 CYP125+androstenedione<br />
Line 147: Line 151:
* P450cam or camphor-5 momooxygenase
* P450cam or camphor-5 momooxygenase
-
**[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]] - PpP450cam - ''Pseudomona putida''<br />
+
**[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]], [[6wpl]] - PpP450cam - ''Pseudomona putida''<br />
**[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]], [[6we6]], [[6wfl]] – PpP450cam (mutant) <br />
**[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]], [[6we6]], [[6wfl]] – PpP450cam (mutant) <br />
**[[2qbo]] - PpP450cam (mutant)+cyanide<br />
**[[2qbo]] - PpP450cam (mutant)+cyanide<br />
Line 253: Line 257:
**[[3wsp]] - BmP450 heme domain + decoy molecule<br />
**[[3wsp]] - BmP450 heme domain + decoy molecule<br />
**[[2uwh]] - BmP450102+palmitic acid<br />
**[[2uwh]] - BmP450102+palmitic acid<br />
-
**[[3ben]] - BmP450 heme domain + inhibitor<br />
+
**[[3ben]], [[7egn]] - BmP450 heme domain + inhibitor<br />
**[[2j1m]] - BmP450102 heme domain +DMSO<br />
**[[2j1m]] - BmP450102 heme domain +DMSO<br />
**[[5jtd]] - BmP450102 heme domain (mutant) +DMSO<br />
**[[5jtd]] - BmP450102 heme domain (mutant) +DMSO<br />
Line 264: Line 268:
**[[6ly4]] - BmP450 heme domain (mutant) + testosterone<br />
**[[6ly4]] - BmP450 heme domain (mutant) + testosterone<br />
**[[5b2u]], [[5b2w]], [[5b2x]] - BmP450 heme domain (mutant) + tryptophan derivative<br />
**[[5b2u]], [[5b2w]], [[5b2x]] - BmP450 heme domain (mutant) + tryptophan derivative<br />
 +
**[[7ckn]], [[7con]], [[7coo]], [[7cp8]], [[7cx8]], [[7d0t]], [[7d0u]], [[7d1f]], [[7e46]], [[7w97]], [[7w9d]], [[7w9j]] - PmP450 heme domain CYP102A1 + inhibitor<br />
**[[4yt3]] - BmP450 CYP106A2 <br />
**[[4yt3]] - BmP450 CYP106A2 <br />
**[[5iki]] - BmP450 CYP106A2 + abietic acid <br />
**[[5iki]] - BmP450 CYP106A2 + abietic acid <br />
Line 269: Line 274:
**[[5l91]], [[5l92]] - BmP450 CYP109E1 + corticosterone<br />
**[[5l91]], [[5l92]] - BmP450 CYP109E1 + corticosterone<br />
**[[5l94]] - BmP450 CYP109E1 + testosterone<br />
**[[5l94]] - BmP450 CYP109E1 + testosterone<br />
 +
**[[7f3h]] - P450 heme domain – ''Deinococcus aerius''<br />
 +
**[[7f3w]] - P450 heme domain – ''Deinococcus apachensis''<br />
 +
 +
*Eukaryote P450 Cyp51 or lanosterol 14-alpha demethylase
 +
 +
**[[3juv]] – hCyp51<br />
 +
**[[3jus]], [[3ld6]], [[4uhi]], [[4uhl]] – hCyp51 + drug<br />
 +
**[[6uez]] – hCyp51 + lanosterol<br />
 +
**[[6q2t]] – hCyp51 + inhibitor<br />
 +
**[[5esi]], [[5esn]] – yCyp51 (mutant) - yeast<br />
 +
**[[5eab]], [[5eac]], [[5ead]], [[5eae]], [[5eaf]], [[5eag]], [[5eah]], [[7ryx]], [[8dl4]] – yCyp51 + inhibitor<br />
 +
**[[4wmz]], [[5eqb]], [[5hs1]], [[5ul0]], [[6e8q]], [[7ryx]] – yCyp51 + drug<br />
 +
**[[4zdy]], [[4zdz]], [[4ze0]], [[4ze1]], [[4ze2]], [[4ze3]], [[5ese]], [[5esf]], [[5esg]], [[5esh]], [[5esj]], [[5esk]], [[5esl]], [[5esm]], [[7ry8]], [[7ry9]], [[7rya]], [[7ryb]] – yCyp51 (mutant) + drug<br />
 +
**[[4lxj]] – yCyp51 + lanosterol<br />
 +
**[[5v5z]] – CaP450 CYP51 – ''Candida albicans''<br />
 +
**[[5tz1]] – CaP450 CYP51 + drug <br />
 +
**[[5fsa]] – CaP450 CYP51 (mutant) + drug <br />
 +
 +
*Bacterial P450 Cyp51 or lanosterol 14-alpha demethylase
 +
 +
**[[6mi0]], [[7jj1]]– McP450 CYP51 – ''Methylcoccus capsulatus''<br />
 +
**[[7tef]] – MmP450 CYP51B1 – ''Mycobacterium marinum''<br />
 +
**[[3g1q]] – TbP450 CYP51 – ''Trypanosoma brucei''<br />
 +
**[[5jlc]] – P450 CYP51 – ''Candida glabrata<''br />
 +
**[[4bmm]], [[4by0]], [[4c0c]], [[4c27]], [[4c28]], [[4coh]], [[4uqh]], [[4uvr]] – P450 CYP51 + inhibitor – ''Trypanosoma cruzi''<br />
 +
**[[6fmo]] – P450 CYP51 (mutant) + obtosifoliol <br />
 +
**[[6mcw]] – McP450 CYP51 + detergent <br />
 +
**[[7snm]] – McP450 CYP51 + drug <br />
 +
**[[7rkr]] – NfP450 CYP51 + inhibitor<br />
 +
**[[2wv2]], [[2wx2]], [[2x2n]], [[3tik]] – TbP450 CYP51 + drug<br />
 +
**[[3gw9]], [[4bjk]], [[4g3j]], [[4g7g]] – TbP450 CYP51 + inhibitor<br />
 +
**[[3p99]] – TbP450 CYP51 + lanosterol derivative<br />
 +
**[[6ay4]], [[6ayb]], [[6ayc]] – NfP450 CYP51 + drug – ''Naegleria fowleri''<br />
 +
**[[3l4d]] – P450 CYP51 + drug – ''Leishmania infantum''<br />
* Other CYPs
* Other CYPs
Line 278: Line 317:
**[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br />
**[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br />
**[[2rfb]] – PtP450 – ''Picrophilus torridus''<br />
**[[2rfb]] – PtP450 – ''Picrophilus torridus''<br />
-
**[[6gii]] – P450 – ''Tepidiphilus thermophilus''<br />
+
**[[6gii]], [[6laa]] – P450 – ''Tepidiphilus thermophilus''<br />
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br />
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br />
**[[4e2p]], [[5xw2]] - P450 – ''Streptococcus himastatinicus''<br />
**[[4e2p]], [[5xw2]] - P450 – ''Streptococcus himastatinicus''<br />
Line 284: Line 323:
**[[5ysm]] – AmP450 – ''Amycolatopsis mediterranei''<br />
**[[5ysm]] – AmP450 – ''Amycolatopsis mediterranei''<br />
**[[6f0c]], [[6f0b]] - P450 TXTC – ''Streptomyces acidiscabies''<br />
**[[6f0c]], [[6f0b]] - P450 TXTC – ''Streptomyces acidiscabies''<br />
-
**[[5gwe]] – CgP450 CREJ – ''Corynebacterium glutamicum''<br />
+
**[[5gwe]], [[7ccf]] – CgP450 CreJ – ''Corynebacterium glutamicum''<br />
**[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br />
**[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br />
**[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br />
**[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br />
Line 292: Line 331:
**[[3a4z]], [[5gnm]], [[5gnl]] - PaP450 VDH (mutant)<br />
**[[3a4z]], [[5gnm]], [[5gnl]] - PaP450 VDH (mutant)<br />
**[[3qi8]] – P450 – synthetic<br />
**[[3qi8]] – P450 – synthetic<br />
-
**[[6mi0]] – McP450 CYP51 – ''Methylcoccus capsulatus''<br />
+
**[[3g1q]] – TbP450 CYP51 – ''Trypanosoma brucei''<br />
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br />
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br />
**[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br />
**[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br />
Line 303: Line 342:
**[[3abb]] – SaP450 CYP105D6 - ''Streptomyces avermitilis''<br />
**[[3abb]] – SaP450 CYP105D6 - ''Streptomyces avermitilis''<br />
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br />
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br />
-
**[[2z3u]] - SsP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br />
+
**[[2z3u]] - SgP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br />
**[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br />
**[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br />
 +
**[[6l39]] - SrP450 CYP107G1 – ''Streptomyces rapamycinicus''<br />
**[[4wpz]] - SaP450 CYP107W1 <br />
**[[4wpz]] - SaP450 CYP107W1 <br />
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
Line 315: Line 355:
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br />
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br />
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br />
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br />
-
**[[6cvc]] – MmP450 CYP124A1 – ''Mycobacterium marinum''<br />
+
**[[6cvc]] – MmP450 CYP124A1<br />
**[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br />
**[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br />
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br />
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br />
 +
**[[7tlo]] – MmP450 CYP142A3 <br />
**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br />
**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br />
**[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br />
**[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br />
**[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br />
**[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br />
**[[6hqd]] – PsP450 CYP153 <br />
**[[6hqd]] – PsP450 CYP153 <br />
 +
**[[7ant]] – PoP450 CYP153 - ''Polaromonas''<br />
**[[1gwi]] - ScP450 CYP154C1<br />
**[[1gwi]] - ScP450 CYP154C1<br />
-
**[[6a7i]] - SvP450 CYP154C4 – ''Streptomyces violaceruber''<br />
+
**[[6a7i]] - SvP450 CYP154C4 – Streptomyces violaceruber<br />
**[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br />
**[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br />
**[[3r9b]] – MsP450 CYP164A2 <br />
**[[3r9b]] – MsP450 CYP164A2 <br />
Line 330: Line 372:
**[[1n97]] – TtP450 CYP175A1<br />
**[[1n97]] – TtP450 CYP175A1<br />
**[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br />
**[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br />
-
**[[2z3t]] - StrP450 CYP245A1 - ''Streptomyces sp.''<br />
+
**[[2z3t]] - StrP450 CYP245A1 <br />
**[[5liv]] - ScP450 CYP260A1 <br />
**[[5liv]] - ScP450 CYP260A1 <br />
**[[6f85]] - ScP450 CYP260A1 (mutant)<br />
**[[6f85]] - ScP450 CYP260A1 (mutant)<br />
**[[5hiw]] - ScP450 CYP260B1 <br />
**[[5hiw]] - ScP450 CYP260B1 <br />
**[[6gk5]] - ScP450 CYP267B1 <br />
**[[6gk5]] - ScP450 CYP267B1 <br />
-
**[[6g71]] - P450 CYP1232A24 - ''Arthrobacter''<br />
+
**[[6g71]] - P450 CYP1232A24 - ''Arthrobacter<''br />
 +
**[[6m4q]] - SspP450 – ''Streptomyces spectabilis''<br />
 +
**[[6j82]] - SbP450 TleB – ''Streptomyces blastmyceticus''<br />
 +
**[[7ayx]] - P450 AryC – ''Streptomyces filamentosus''<br />
 +
**[[7oq6]] - P450 Sas16 –'' Streptomyces calvus''<br />
 +
**[[6kbh]] – ReP450 – ''Rhodococcus erythropolis''<br />
 +
**[[7v40]] – RcP450 – ''Rhodococcus coprophilus''<br />
 +
**[[6zhz]] - SanP450 – ''Streptomyces antibioticus''<br />
 +
**[[7qan]] - P450 – ''Micromonospora maris"<br />
*Other CYPs complexes
*Other CYPs complexes
**[[2rfc]] – PtP450+phenylimidazole<br />
**[[2rfc]] – PtP450+phenylimidazole<br />
-
**[[3wec]] – P450 + dihydroxy-aurachin Re – ''Rhodococcus erythropolis''<br />
+
**[[3wec]] – ReP450 + dihydroxy-aurachin Re <br />
**[[5ysw]] – AmP450+ rifamycin <br />
**[[5ysw]] – AmP450+ rifamycin <br />
**[[5omu]] – AmP450+ syringol <br />
**[[5omu]] – AmP450+ syringol <br />
Line 355: Line 405:
**[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br />
**[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br />
**[[5xjn]] – CgP450 CREJ + ethylphenyl derivative<br />
**[[5xjn]] – CgP450 CREJ + ethylphenyl derivative<br />
-
**[[5fsa]] – P450 CYP51 (mutant) + posaconazole – ''Candida albicans''<br />
 
-
**[[6fmo]] – P450 CYP51 (mutant) + obtosifoliol – ''Trypanosoma cruzi''<br />
 
-
**[[6mcw]] – McP450 CYP51 + detergent <br />
 
**[[2rch]], [[3dsi]] – AtP450 CYP74A+13(S)-HOD <br />
**[[2rch]], [[3dsi]] – AtP450 CYP74A+13(S)-HOD <br />
**[[3dsj]] - AtP450 CYP74A (mutant)+13(S)-HOD<br />
**[[3dsj]] - AtP450 CYP74A (mutant)+13(S)-HOD<br />
**[[2rcl]] - AtP450 CYP74A+vernolic acid<br />
**[[2rcl]] - AtP450 CYP74A+vernolic acid<br />
-
**[[3dsk]] - AtP450 CYP74A (mutant)+ vernolic acid<br />
+
**[[7p6l]] - P450 CYP505A30 + dodecanoic acid – ''Mycelyophthora thermophila"<br />
**[[6a15]] - AtP450 CYP90B1 (mutant) + cholesterol<br />
**[[6a15]] - AtP450 CYP90B1 (mutant) + cholesterol<br />
**[[6a16]] - AtP450 CYP90B1 (mutant) + uniconazole<br />
**[[6a16]] - AtP450 CYP90B1 (mutant) + uniconazole<br />
Line 370: Line 417:
**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br />
**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br />
**[[2zbx]] - SgP450 CYP105A1+imidazole<br />
**[[2zbx]] - SgP450 CYP105A1+imidazole<br />
-
**[[5x7e]] - SsP450 CYP105A1 (mutant)+vitamin D2<br /
+
**[[5x7e]] - SgP450 CYP105A1 (mutant)+vitamin D2<br /
**[[3aba]] – SaP450 CYP105P1+filipin I <br />
**[[3aba]] – SaP450 CYP105P1+filipin I <br />
**[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br />
**[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br />
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br />
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br />
 +
**[[7q9e]] - PmP450 CYP106A1 – Priestia megaterium<br />
 +
**[[7cvr]], [[7cx6]], [[7czi]] - PmP450 CYP106A1 + inhibitor<br />
**[[1jin]], [[1jip]] - SeP450 CYP107A1+ ketoconazole <br />
**[[1jin]], [[1jip]] - SeP450 CYP107A1+ ketoconazole <br />
**[[1jio]], [[1oxa]] - SeP450 CYP107A1+6DEB<br />
**[[1jio]], [[1oxa]] - SeP450 CYP107A1+6DEB<br />
**[[1eup]] – SeP450 CYP107A1+androstendione<br />
**[[1eup]] – SeP450 CYP107A1+androstendione<br />
**[[1egy]] - SeP450 CYP107A1+aminophenanthrene<br />
**[[1egy]] - SeP450 CYP107A1+aminophenanthrene<br />
 +
**[[6kzs]] - SgP450 CYP107F1 + imidazole<br />
 +
**[[6l3a]] - SrP450 CYP107G1 + drug<br />
**[[4wq0]] - SaP450 CYP107W1 + oligomycin<br />
**[[4wq0]] - SaP450 CYP107W1 + oligomycin<br />
**[[2vzm]] – SvP450 CYP107L1 (mutant)+narbomycin<br />
**[[2vzm]] – SvP450 CYP107L1 (mutant)+narbomycin<br />
**[[2c7x]] - SvP450 CYP107L1+narbomycin<br />
**[[2c7x]] - SvP450 CYP107L1+narbomycin<br />
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450 CYP107L1+YC-17<br />
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450 CYP107L1+YC-17<br />
-
**[[2jjp]] - SeP450 CYP113A1 (mutant)+ketoconazole<br />
 
-
**[[2xfh]] - SeP450 CYP113A1 (mutant)+clotrimazole<br />
 
-
**[[1f4t]] - SsP450 CYP119+ phenylimidazole<br />
 
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
 +
**[[7smz]] – MmP450 CYP142A3 + cholestenone<br />
**[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br />
**[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br />
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br />
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br />
 +
**[[7ao7]] – PoP450 CYP153 + octanol <br />
 +
**[[6to2]] - NfP450 CYP154C4 + androstan derivative – ''Nocardia farcinica'' <br />
 +
**[[4j6b]], [[4jbc]], [[4jbd]], [[4jbt]] - NfP450 CYP154C5 + hormone<br />
**[[6a7j]] - SvP450 CYP154C4 + testosterone <br />
**[[6a7j]] - SvP450 CYP154C4 + testosterone <br />
**[[3r9c]] – MsP450 CYP164A2 + econazole<br />
**[[3r9c]] – MsP450 CYP164A2 + econazole<br />
-
**[[4do1]], [[4egm]], [[6c3j]], [[6c3h]], [[6c2d]], [[5yqh]], [[5yqa]], [[5uvb]], [[5u6w]], [[5u6u]], [[5u6t]], [[5kt1]], [[5kdb]], [[6oow]], [[6pq6]], [[6pqd]], [[6pqs]], [[6pqw]], [[6prr]], [[6prs]], [[6u30]], [[6u3k]] – RpP450 CYP199A4 + benzoate derivative<br />
+
**[[4do1]], [[4egm]], [[6c3j]], [[6c3h]], [[6c2d]], [[5yqh]], [[5yqa]], [[5uvb]], [[5u6w]], [[5u6u]], [[5u6t]], [[5kt1]], [[5kdb]], [[6oow]], [[6pq6]], [[6pqd]], [[6pqs]], [[6pqw]], [[6prr]], [[6prs]], [[6u30]], [[6u31]], [[6u3k]], [[7jw5]], [[7jxb]], [[7kcs]], [[7n14]], [[7r8s]], [[7r8t]], [[7reh]] – RpP450 CYP199A4 + benzoate derivative<br />
-
**[[5kdz]], [[5kdy]], [[6oox]] – RpP450 CYP199A4 (mutant) + benzoate derivative<br />
+
**[[5kdz]], [[5kdy]], [[6oox]] , [[7n60]]– RpP450 CYP199A4 (mutant) + benzoate derivative<br />
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br />
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br />
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br />
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br />
 +
**[[6unn]] – RpP450 CYP199A4 + cinnamic acid derivative<br />
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br />
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br />
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br />
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br />
Line 402: Line 455:
**[[4r20]] - zP450 17A2 + abiraterone – zebra fish<br />
**[[4r20]] - zP450 17A2 + abiraterone – zebra fish<br />
**[[6b82]] - zP450 17A1 (mutant) + abiraterone <br />
**[[6b82]] - zP450 17A1 (mutant) + abiraterone <br />
 +
**[[4r21]] - zP450 17A2 + progesterone<br />
 +
**[[6m4p]] - SspP450 + antibiotic <br />
 +
**[[6zi3]], [[7zi7]] - SanP450 + rhamnose <br />
 +
**[[7q6x]] - SanP450 + erythronolide<br />
 +
**[[7q6r]], [[7q89]] - SanP450 (mutant) + erythronolide<br />
 +
**[[6j84]] - SbP450 TleB + hydroxyl analog<br />
 +
**[[6j83]] - SbP450 TleB + NMVT<br />
 +
**[[7v41]], [[7v45]], [[7v46]] – RcP450 + toluene derivative<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Cytochrome P450

Updated on 15-December-2022

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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