D-xylose isomerase

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<StructureSection load='1xld' size='350' side='right' caption='Structure of D-xylose isomerase complex with D-xylose and Mn+2 ions (purple) (PDB code [[1xld]]).' scene='52/525128/Cv/1'>
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<StructureSection load='' size='350' side='right' caption='Structure of D-xylose isomerase complex with D-xylose and Mn+2 ions (purple) (PDB code [[1xld]]).' scene='52/525128/Cv/1'>
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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DXI active site contains 2 Mn<sup>+2</sup> ions and the ligand binding pocket is composed of aromatic and acidic residues.<ref>PMID:2319597</ref>
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<scene name='52/525128/Cv/7'>The biological assembly of D-xylose isomerase</scene> from ''Arthrobacter sp'' is homotetramer. DXI active site contains <scene name='52/525128/Cv/8'>2 Mn+2 ions</scene> and the <scene name='52/525128/Cv/9'>ligand binding pocket is composed of aromatic and acidic residues</scene> (water molecules shown as red spheres).<ref>PMID:2319597</ref>
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</StructureSection>
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==3D structures of D-xylose isomerase==
==3D structures of D-xylose isomerase==
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[[D-xylose isomerase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*D-xylose isomerase
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**[[6xia]] – DXI – ''Streptomyces albus''<br />
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**[[1xla]], [[1xia]] – ArDXI – ''Arthrobacter''<br />
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**[[3xin]], [[7xim]] - AmDXI - ''Actinoplanes missouriensis''<br />
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**[[1bhw]] - AmDXI (mutant) <br />
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**[[1bxb]], [[1bxc]] - DXI – ''Thermus thermophilus''<br />
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**[[2gub]], [[3kbj]], [[3kcj]] – SrDXI - ''Streptomyces rubiginosus''<br />
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**[[3qza]] - SrDXI - neutron
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*Mn-containing DXI
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**[[1xis]], [[1xib]], [[1xij]], [[2glk]], [[3n4a]] – SrDXI + Mn<br />
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**[[2gyi]] - SoDXI + Mn – ''Streptomyces olivochromogenos''<br />
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**[[1xle]], [[1xlk]] - ArDXI + Mn<br />
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**[[1a0d]] - DXI + Mn – ''Bacillus stearothermophilus''
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*''Mn-containing DXI complex''
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**[[4xis]], [[1xic]] - SrDXI + DX + Mn<br />
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**[[1xld]], [[1xlj]] - ArDXI + xylitol + Mn<br />
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**[[1xig]], [[3gnx]] - SrDXI + xylitol + Mn<br />
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**[[1s5n]] - SoDXI + xylitol + Mn<br />
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**[[1xii]] - SrDXI + xylulose + Mn<br />
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**[[8xia]] – SrDXI + DX + Mn<br />
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**[[9xia]] – SrDXI + fructose + Mn<br />
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**[[1xif]] - SrDXI + glucose + Mn<br />
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**[[1s5m]] - SoDXI + glucose + Mn<br />
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**[[1xid]] - SrDXI + ascorbate + Mn<br />
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**[[1xie]], [[1xih]] - SrDXI + sorbitol + Mn<br />
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**[[1did]] - ArDXI + glucitol + Mn<br />
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**[[1xlf]] - ArDXI + gluconic acid + Mn<br />
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**[[1xli]] - ArDXI + glucose derivative + Mn<br />
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*Mg-containing DXI
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**[[1xlb]] - ArDXI + Mg<br />
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**[[1xya]], [[1xyl]] - SoDXI + Mg<br />
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**[[3u3h]] - SrDXI + Mg<br />
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**[[1dxi]] - DXI + Mg – ''Streptomyces murinus''<br />
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*''Mg-containing DXI complex''
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**[[1xyb]], [[1xym]] - SoDXI + glucose + Mg<br />
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**[[1xyc]] - SoDXI + fructose + Mg<br />
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**[[4xia]], [[5xim]] – ArDXI + sorbitol + Mg<br />
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**[[5xia]], [[1xlc]], [[1xlg]] – ArDXI + xylitol + Mg<br />
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**[[2xis]], [[4duo]] - SrDXI + xylitol + Mg<br />
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**[[3cwh]] - SrDXI + xylulose + Mg<br />
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**[[2xim]], [[1xin]] - AmDXI + xylitol + Mg<br />
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**[[5xin]], [[6xim]], [[8xim]], [[9xim]] - AmDXI + DX + Mg<br />
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**[[3xis]] - SrDXI + DX + Mg<br />
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**[[1die]] - ArDXI + moranoline + Mg<br />
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*Co-containing DXI
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**[[4xim]] - AmDXI + Co<br />
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**[[1a0c]] - DXI + Co – ''Thermoanaerobacterium''<br />
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**[[1a0e]] - DXI + Co – ''Thermotoga neapolitana''<br />
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**[[1qt1]] - SdDXI + Co – ''Streptomyces diastaticus''<br />
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**[[2gve]], [[4a8i]], [[4a8l]], [[4a8r]], [[4a8n]] - SrDXI + Co<br />
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*''Co-containing DXI complex''
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**[[1xim]] - AmDXI + xylitol + Co<br />
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**[[3xim]], [[2xin]] - AmDXI + sorbitol + Co<br />
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*Al-containing DXI
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**[[1xlh]] - ArDXI + Al<br />
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**[[1xlm]] - ArDXI (mutant) + xylitol + Al
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*Zn-containing DXI
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**[[1xll]] - ArDXI + Zn
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*Cd-containing DXI
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**[[3kbs]] - SrDXI + Cd<br />
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**[[3kbm]], [[3kcl]] - SrDXI + glucose + Cd
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*Ni-containing DXI
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**[[3kbv]], [[3qys]] - SrDXI + Ni<br />
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**[[3kbn]], [[3kco]] - SrDXI + glucose + Ni<br />
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**[[4dvo]] - SrDXI + sorbitol + Ni
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*Ca-containing DXI
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**[[1gw9]] - SrDXI + DX + Ca
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*Bi-metal-containing DXI
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**[[1mnz]], [[1o1h]], [[2g4j]] - SrDXI + Mg + Ca<br />
 
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**[[1oad]], [[4e3v]] - SrDXI + Mg + Mn<br />
 
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**[[1muw]] - SoDXI + Mg + Mn<br />
 
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**[[1clk]] - SdDXI + Co + Mg<br />
 
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**[[4hhl]] – StrDXI + Co + Mg – ''Streptomyces'' <br />
 
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**[[4hhm]] – StrDXI (mutant) + Co + Mg <br />
 
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**[[3kbw]] - SrDXI + Ni + Mg<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of D-xylose isomerase complex with D-xylose and Mn+2 ions (purple) (PDB code 1xld).

Drag the structure with the mouse to rotate

References

  1. ↑ MARSHALL RO, KOOI ER. Enzymatic conversion of D-glucose to D-fructose. Science. 1957 Apr 5;125(3249):648-9. PMID:13421660
  2. ↑ Collyer CA, Henrick K, Blow DM. Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift. J Mol Biol. 1990 Mar 5;212(1):211-35. PMID:2319597

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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