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4lzs
From Proteopedia
(Difference between revisions)
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==Crystal Structure of BRD4(1) bound to inhibitor XD46== | ==Crystal Structure of BRD4(1) bound to inhibitor XD46== | ||
| - | <StructureSection load='4lzs' size='340' side='right' caption='[[4lzs]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='4lzs' size='340' side='right'caption='[[4lzs]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4lzs]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4lzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LZS FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L46:4-ACETYL-3-ETHYL-N,5-DIMETHYL-1H-PYRROLE-2-CARBOXAMIDE'>L46</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L46:4-ACETYL-3-ETHYL-N,5-DIMETHYL-1H-PYRROLE-2-CARBOXAMIDE'>L46</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lzs OCA], [https://pdbe.org/4lzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lzs RCSB], [https://www.ebi.ac.uk/pdbsum/4lzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lzs ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Bromodomain-containing protein|Bromodomain-containing protein]] | + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Einsle | + | [[Category: Large Structures]] |
| - | [[Category: Gerhardt | + | [[Category: Einsle O]] |
| - | [[Category: Huegle | + | [[Category: Gerhardt S]] |
| - | [[Category: Wohlwend | + | [[Category: Huegle M]] |
| - | + | [[Category: Wohlwend D]] | |
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Revision as of 10:43, 21 December 2022
Crystal Structure of BRD4(1) bound to inhibitor XD46
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