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4m60

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==Crystal structure of macrolide glycosyltransferases OleD==
==Crystal structure of macrolide glycosyltransferases OleD==
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<StructureSection load='4m60' size='340' side='right' caption='[[4m60]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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<StructureSection load='4m60' size='340' side='right'caption='[[4m60]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m60]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M60 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4m60]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M60 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m60 OCA], [https://pdbe.org/4m60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m60 RCSB], [https://www.ebi.ac.uk/pdbsum/4m60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m60 ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2iyf|2iyf]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">oleD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1890 Streptomyces antibioticus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m60 RCSB], [http://www.ebi.ac.uk/pdbsum/4m60 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OLED_STRAT OLED_STRAT] Specifically inactivates oleandomycin via 2'-O-glycosylation using UDP-glucose.
==See Also==
==See Also==
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*[[Glycosyltransferase|Glycosyltransferase]]
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces antibioticus]]
[[Category: Streptomyces antibioticus]]
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[[Category: Bingman, C A]]
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[[Category: Bingman CA]]
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[[Category: Helmich, K E]]
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[[Category: Helmich KE]]
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[[Category: III, E Martinez]]
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[[Category: Martinez III E]]
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[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis]]
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[[Category: Olmos Jr JL]]
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[[Category: Olmos, J L]]
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[[Category: Phillips Jr GN]]
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[[Category: Phillips, G N]]
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[[Category: Singh S]]
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[[Category: Singh, S]]
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[[Category: Thorson JS]]
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[[Category: Thorson, J S]]
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[[Category: Wang F]]
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[[Category: Wang, F]]
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[[Category: Xu W]]
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[[Category: Xu, W]]
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[[Category: Enzyme discovery for natural product biosynthesis]]
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[[Category: Natpro]]
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[[Category: Oleandomycin glycosyltransferase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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Current revision

Crystal structure of macrolide glycosyltransferases OleD

PDB ID 4m60

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