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4m6x

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<StructureSection load='4m6x' size='340' side='right'caption='[[4m6x]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4m6x' size='340' side='right'caption='[[4m6x]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_hygroscopicus"_jensen_1931 "actinomyces hygroscopicus" jensen 1931]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M6X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4m6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_hygroscopicus Streptomyces hygroscopicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M6X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=56D:(3R)-2-OXO-3-PHENYLBUTANOIC+ACID'>56D</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=56D:(3R)-2-OXO-3-PHENYLBUTANOIC+ACID'>56D</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kib|4kib]], [[4m6y|4m6y]], [[4m71|4m71]], [[4m72|4m72]], [[4m73|4m73]], [[4m74|4m74]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6x OCA], [https://pdbe.org/4m6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m6x RCSB], [https://www.ebi.ac.uk/pdbsum/4m6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6x ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mppJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1912 "Actinomyces hygroscopicus" Jensen 1931])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6x OCA], [http://pdbe.org/4m6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m6x RCSB], [http://www.ebi.ac.uk/pdbsum/4m6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6x ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MPPJ_STRHY MPPJ_STRHY]] S-adenosyl-L-methionine-dependent methyltransferase involved in synthesis of the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.
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[https://www.uniprot.org/uniprot/MPPJ_STRHY MPPJ_STRHY] S-adenosyl-L-methionine-dependent methyltransferase involved in synthesis of the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[SAM-dependent methyltransferase|SAM-dependent methyltransferase]]
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*[[SAM-dependent methyltrasferase 3D structures|SAM-dependent methyltrasferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces hygroscopicus jensen 1931]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chan, H C]]
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[[Category: Streptomyces hygroscopicus]]
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[[Category: Huang, C J]]
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[[Category: Chan HC]]
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[[Category: Li, T L]]
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[[Category: Huang CJ]]
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[[Category: Liu, Y C]]
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[[Category: Li TL]]
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[[Category: Zou, X W]]
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[[Category: Liu YC]]
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[[Category: Methyltransferase]]
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[[Category: Zou XW]]
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[[Category: Rossmann fold]]
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[[Category: Sam/ppy binding]]
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[[Category: Transferase]]
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Revision as of 11:00, 21 December 2022

Mutant structure of methyltransferase from Streptomyces hygroscopicus complexed with S-adenosyl-L-homocysteine and methylphenylpyruvic acid

PDB ID 4m6x

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