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4mf3

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==Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist==
==Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist==
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<StructureSection load='4mf3' size='340' side='right' caption='[[4mf3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4mf3' size='340' side='right'caption='[[4mf3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mf3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MF3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MF3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mf3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MF3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXI:(3S,4AS,6S,8AR)-6-[3-CHLORO-2-(1H-TETRAZOL-5-YL)PHENOXY]DECAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>SXI</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SXI:(3S,4AS,6S,8AR)-6-[3-CHLORO-2-(1H-TETRAZOL-5-YL)PHENOXY]DECAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>SXI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mf3 OCA], [http://pdbe.org/4mf3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mf3 RCSB], [http://www.ebi.ac.uk/pdbsum/4mf3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mf3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mf3 OCA], [https://pdbe.org/4mf3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mf3 RCSB], [https://www.ebi.ac.uk/pdbsum/4mf3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mf3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GRIK1_HUMAN GRIK1_HUMAN]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
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[https://www.uniprot.org/uniprot/GRIK1_HUMAN GRIK1_HUMAN] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4mf3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4mf3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alt, A]]
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[[Category: Homo sapiens]]
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[[Category: Arnold, B M]]
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[[Category: Large Structures]]
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[[Category: Bell, M G]]
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[[Category: Alt A]]
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[[Category: Bleakman, D]]
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[[Category: Arnold BM]]
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[[Category: Bleisch, T J]]
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[[Category: Bell MG]]
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[[Category: Castano, A M]]
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[[Category: Bleakman D]]
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[[Category: Clawson, D K]]
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[[Category: Bleisch TJ]]
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[[Category: Dominguez, E]]
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[[Category: Castano AM]]
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[[Category: Escribano, A M]]
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[[Category: Clawson DK]]
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[[Category: Filla, S A]]
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[[Category: Del Prado M]]
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[[Category: Ho, K H]]
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[[Category: Dominguez E]]
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[[Category: Hudziak, K J]]
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[[Category: Escribano AM]]
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[[Category: Iyengar, S]]
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[[Category: Filla SA]]
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[[Category: Jones, C K]]
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[[Category: Ho KH]]
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[[Category: Katofiasc, M A]]
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[[Category: Hudziak KJ]]
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[[Category: Martinez-Perez, J A]]
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[[Category: Iyengar S]]
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[[Category: Mateo, A]]
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[[Category: Jones CK]]
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[[Category: Mathes, B M]]
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[[Category: Katofiasc MA]]
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[[Category: Mattiuz, E L]]
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[[Category: Martinez-Perez JA]]
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[[Category: Ogden, A M.L]]
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[[Category: Mateo A]]
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[[Category: Ornstein, P L]]
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[[Category: Mathes BM]]
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[[Category: Phebus, L A]]
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[[Category: Mattiuz EL]]
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[[Category: Prado, M Del]]
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[[Category: Ogden AML]]
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[[Category: Shannon, H E]]
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[[Category: Ornstein PL]]
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[[Category: Simmons, R M.A]]
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[[Category: Phebus LA]]
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[[Category: Stack, D R]]
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[[Category: Shannon HE]]
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[[Category: Stratford, R E]]
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[[Category: Simmons RMA]]
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[[Category: Winter, M A]]
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[[Category: Stack DR]]
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[[Category: Wu, Z]]
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[[Category: Stratford RE]]
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[[Category: Glutamate binding]]
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[[Category: Winter MA]]
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[[Category: Glutamate receptor]]
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[[Category: Wu Z]]
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[[Category: Ligand gated ion channel]]
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[[Category: Membrane]]
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[[Category: None]]
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[[Category: Protein-ligand complex]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist

PDB ID 4mf3

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