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4mfu

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Revision as of 11:14, 21 December 2022

Crystal structure of human CTNNBL1(residues 77~563)

Structural highlights

4mfu is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CTBL1_HUMAN Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.^[1] ^[2]

Publication Abstract from PubMed

The hPrp19-CDC5L complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome. In order to elucidate the molecular architecture of the hPrp19-CDC5L complex, the crystal structure of CTNNBL1, one of the major components of this complex, was determined. Unlike canonical ARM-repeat proteins such as beta-catenin and importin-alpha, CTNNBL1 was found to contain a twisted and extended ARM-repeat structure at the C-terminal domain and, more importantly, the protein formed a stable dimer. A highly negatively charged patch formed in the N-terminal ARM-repeat domain of CTNNBL1 provides a binding site for CDC5L, a binding partner of the protein in the hPrp19-CDC5L complex, and these two proteins form a complex with a stoichiometry of 2:2. These findings not only present the crystal structure of a novel ARM-repeat protein, CTNNBL1, but also provide insights into the detailed molecular architecture of the hPrp19-CDC5L complex.

Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex.,Ahn JW, Kim S, Kim EJ, Kim YJ, Kim KJ Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):780-8. doi:, 10.1107/S139900471303318X. Epub 2014 Feb 22. PMID:24598747^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Jabbour L, Welter JF, Kollar J, Hering TM. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Genomics. 2003 Mar;81(3):292-303. PMID:12659813
↑ Conticello SG, Ganesh K, Xue K, Lu M, Rada C, Neuberger MS. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell. 2008 Aug 22;31(4):474-84. doi: 10.1016/j.molcel.2008.07.009. PMID:18722174 doi:10.1016/j.molcel.2008.07.009
↑ Ahn JW, Kim S, Kim EJ, Kim YJ, Kim KJ. Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):780-8. doi:, 10.1107/S139900471303318X. Epub 2014 Feb 22. PMID:24598747 doi:http://dx.doi.org/10.1107/S139900471303318X

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mfu"

Categories: Homo sapiens | Large Structures | Ahn JW | Kim KJ | Kim S

@@ Line 1: / Line 1: @@
 ==Crystal structure of human CTNNBL1(residues 77~563)==
-<StructureSection load='4mfu' size='340' side='right' caption='[[4mfu]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
+<StructureSection load='4mfu' size='340' side='right'caption='[[4mfu]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4mfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MFU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4mfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MFU FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mfv|4mfv]]</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mfu OCA], [https://pdbe.org/4mfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mfu RCSB], [https://www.ebi.ac.uk/pdbsum/4mfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mfu ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTNNBL1, C20orf33, PP8304 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mfu OCA], [http://pdbe.org/4mfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mfu RCSB], [http://www.ebi.ac.uk/pdbsum/4mfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mfu ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
+[https://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Ahn, J W]]
+[[Category: Large Structures]]
-[[Category: Kim, K J]]
+[[Category: Ahn JW]]
-[[Category: Kim, S]]
+[[Category: Kim KJ]]
-[[Category: Arm repeat]]
+[[Category: Kim S]]
-[[Category: Gene regulation]]

4mfu

From Proteopedia

Revision as of 11:14, 21 December 2022

Crystal structure of human CTNNBL1(residues 77~563)

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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