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4mr1
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4mr1 is ON HOLD Authors: Merlino, A. Description: X-ray structure of the adduct between hen egg white lysozyme and cis-diamminediiodoplatinum(II)) |
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of the adduct between hen egg white lysozyme and cis-diamminediiodoplatinum(II)== | |
| + | <StructureSection load='4mr1' size='340' side='right'caption='[[4mr1]], [[Resolution|resolution]] 1.99Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4mr1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MR1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YPT:CIS-DIAMINO(DIIODO)PLATINUM'>YPT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mr1 OCA], [https://pdbe.org/4mr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mr1 RCSB], [https://www.ebi.ac.uk/pdbsum/4mr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mr1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The reactivity of cis-diamminediiodidoplatinum(II), cis-PtI2(NH3)2, the iodo analogue of cisplatin, with hen egg white lysozyme (HEWL) was investigated by electrospray ionization mass spectrometry and X-ray crystallography. Interestingly, the study compound forms a stable 1:1 protein adduct for which the crystal structure was solved at 1.99 A resolution. In this adduct, the Pt(II) center, upon release of one ammonia ligand, selectively coordinates to the imidazole of His15. Both iodide ligands remain bound to platinum, with this being a highly peculiar and unexpected feature. Notably, two equivalent modes of Pt(II) binding are possible that differ only in the location of I atoms with respect to ND1 of His15. The structure of the adduct was compared with that of HEWL-cisplatin, previously described; differences are stressed and their important mechanistic implications discussed. | ||
| - | + | Peculiar features in the crystal structure of the adduct formed between cis-PtI2(NH3)2 and hen egg white lysozyme.,Messori L, Marzo T, Gabbiani C, Valdes AA, Quiroga AG, Merlino A Inorg Chem. 2013 Dec 16;52(24):13827-9. doi: 10.1021/ic402611m. Epub 2013 Nov 20. PMID:24256441<ref>PMID:24256441</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4mr1" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gallus gallus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Merlino A]] | ||
Current revision
X-ray structure of the adduct between hen egg white lysozyme and cis-diamminediiodoplatinum(II)
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