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4n3m

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==Joint neutron/X-ray structure of urate oxidase in complex with 8-azaxanthine==
==Joint neutron/X-ray structure of urate oxidase in complex with 8-azaxanthine==
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<StructureSection load='4n3m' size='340' side='right' caption='[[4n3m]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4n3m' size='340' side='right'caption='[[4n3m]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4n3m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N3M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4n3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N3M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3m OCA], [https://pdbe.org/4n3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n3m RCSB], [https://www.ebi.ac.uk/pdbsum/4n3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3m ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2iba|2iba]], [[4n9m|4n9m]], [[4n9s|4n9s]], [[4n9v|4n9v]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">uaZ, uox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5059 ASPFL])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n3m RCSB], [http://www.ebi.ac.uk/pdbsum/4n3m PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
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[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4n3m" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Urate Oxidase|Urate Oxidase]]
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*[[Urate oxidase 3D structures|Urate oxidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aspfl]]
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[[Category: Aspergillus flavus]]
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[[Category: Factor independent urate hydroxylase]]
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[[Category: Large Structures]]
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[[Category: Blakeley, M P]]
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[[Category: Blakeley MP]]
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[[Category: Budayova-Spano, M]]
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[[Category: Budayova-Spano M]]
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[[Category: Oksanen, E]]
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[[Category: Oksanen E]]
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[[Category: Oxidoreductase]]
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[[Category: Urate oxidase]]
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[[Category: Uricase]]
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Current revision

Joint neutron/X-ray structure of urate oxidase in complex with 8-azaxanthine

PDB ID 4n3m

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