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4n9n

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==Crystal Structure of Saccharomyces cerevisiae Upc2 Transcription Factor fused with T4 Lysozyme==
==Crystal Structure of Saccharomyces cerevisiae Upc2 Transcription Factor fused with T4 Lysozyme==
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<StructureSection load='4n9n' size='340' side='right' caption='[[4n9n]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='4n9n' size='340' side='right'caption='[[4n9n]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4n9n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4n9n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9N FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9n OCA], [http://pdbe.org/4n9n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n9n RCSB], [http://www.ebi.ac.uk/pdbsum/4n9n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9n OCA], [https://pdbe.org/4n9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9n RCSB], [https://www.ebi.ac.uk/pdbsum/4n9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UPC2_YEAST UPC2_YEAST]] Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters. May be involved in down-regulation of CWP2 during anaerobic adaptation.<ref>PMID:11238402</ref> <ref>PMID:11292809</ref> <ref>PMID:11533229</ref> <ref>PMID:12077145</ref> <ref>PMID:12673627</ref>
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[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/UPC2_YEAST UPC2_YEAST] Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters. May be involved in down-regulation of CWP2 during anaerobic adaptation.<ref>PMID:11238402</ref> <ref>PMID:11292809</ref> <ref>PMID:11533229</ref> <ref>PMID:12077145</ref> <ref>PMID:12673627</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Im, Y J]]
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[[Category: Escherichia virus T4]]
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[[Category: Yang, H]]
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[[Category: Large Structures]]
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[[Category: Ergosterol binding]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Fungal nuclear receptor-like transcription factor]]
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[[Category: Im YJ]]
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[[Category: Nucleus]]
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[[Category: Yang H]]
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[[Category: Transcription]]
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Current revision

Crystal Structure of Saccharomyces cerevisiae Upc2 Transcription Factor fused with T4 Lysozyme

PDB ID 4n9n

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